Publications by authors named "An-Qi Han"
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Hepatobiliary Pancreat Dis Int
April 2024
Article Synopsis
- - The study investigates the role of γ-tubulin (TuBG1) in hepatocellular cancer (HCC) and its association with clinical parameters and patient survival, using bioinformatics and experimental methods to analyze and validate findings.
- - Researchers found that TuBG1 is highly expressed in HCC tissues, and silencing its expression led to inhibited cell proliferation and invasion, and increased apoptosis, indicating its potential as a therapeutic target.
- - An immune prognosis model based on TuBG1-related immune genes was developed, showing that higher TuBG1 levels correlate with poorer overall survival in HCC patients, which may help in evaluating patient prognosis.
Background: Although ALYREF has been demonstrated to have a role in a number of malignancies, its role in hepatocellular carcinoma (HCC) has received little attention. Our objective was to research at the prognostic value, biological role and relevance of ALYREF to the immune system in HCC.
Methods: The expression of ALYREF and its relationship with clinical parameters of HCC patients were analyzed by liver cancer cohort (LIHC) of The Cancer Genome Atlas.