Publications by authors named "An-Na Zhu"

Article Synopsis
  • Alocasia macrorrhiza, a significant landscape and medicinal plant in China, showed 40% symptomatic incidence of yellowing and wilting leaves on Hainan Island in 2022.
  • Symptoms were linked to a phytoplasma pathogen, leading researchers to collect samples for DNA analysis.
  • Through PCR amplification and sequencing, the associated phytoplasma was classified as Alocasia macrorrhiza yellows (AmY) with identical sequences, confirming its identity in GenBank.
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  • Palm is a key cash crop in Hainan Island, China, but is severely impacted by palm yellow leaf (AcYL) disease caused by phytoplasmas.
  • The study identified AcYL phytoplasmas as related to 'Phytoplasma malaysianum' from the 16SrXXXII-D subgroup, demonstrating 100% genetic similarity among the strains.
  • A new subgroup, 16SrXXXII-F, was proposed based on genetic analysis, which could help in understanding and managing the spread of AcYL disease in palm plants.
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  • The study identified and characterized pathogens linked to Huanglongbing symptoms in citrus crops on Hainan Island, focusing on phytoplasma and Liberibacter asiaticus.
  • Detection methods included analyzing gene fragments specific to these pathogens, revealing mixed infections and specific subgroups of phytoplasmas present in diseased plants.
  • This research marks the first report of 16SrII-V and 16SrXXXII-D subgroup phytoplasmas infecting citrus in China, as well as instances of co-infection with Liberibacter asiaticus.
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Carica papaya Linn, belonging to the Caricaceae family, is an economic and medicinal plant, which is widely cultivated in tropical and subtropical countries (Soib et al., 2020). Beginning in 2021, abnormal symptoms of Carica papaya exhibiting leaf yellow, crinkle and leaflet were found in Wanning city of Hainan Province, China.

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Background: The China-Gates TB project Phase II implemented case-based payment reform in three Chinese counties in 2014, designed specifically for patients diagnosed with Tuberculosis (TB). This study aimed to examine the changes in utilization and expenses of outpatient services before and after the reform implementation, among TB patients in the three counties in China.

Methods: We collected quantitative data using surveys in 2013 (baseline year) and 2015 (final year).

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  • The study assessed the characteristics, treatments, and outcomes of 16 patients with uterine malignant mixed Mullerian tumor over a 12-year period.
  • Most patients were postmenopausal with a median age of 58, and survival rates indicated that stage and treatment choices heavily influenced prognosis.
  • Uterine segment diagnostic curettage proved to be effective for diagnosis, and factors like early diagnosis and appropriate treatments significantly improved patient outcomes.
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  • * The study analyzed 32 single-nucleotide polymorphisms (SNPs) in estrogen-related genes among 1,076 Han Chinese women, using statistical methods to compare genetic variations between those with breast cancer and those without.
  • * Significant associations were found between specific SNPs (rs700519 and rs2069522) and breast cancer risk, particularly regarding estrogen receptor (ER) and progesterone receptor (PR) statuses, indicating potential genetic factors influencing susceptibility in this population.
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Objective: To investigate the inhibitory effects of tetramethoxystilbene, a selective CYP1B1 inhibitor, on adipogenic differentiation of C3H10T1/2 multi-potent mesenchymal cells.

Methods: In vitro cultured C3H10T1/2 cells at full confluence were induced by adipogenic agents (10 µg/ml insulin, 2 µmol/L dexamethasone and 0.5 mmol/L 3-isobutyl-1-methylxanthine) and exposed simultaneously to TMS at the final concentrations of 1.

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Objectives: To investigate the relationships between single-nucleotide polymorphisms (SNPs) in NOTCH4 and brain-derived neurotrophic factor (BDNF) with schizophrenia among Han Chinese in Southern China.

Methods: Two NOTCH4 SNPs (rs520688 and rs415929) and two BDNF SNPs (rs2030324 and rs12273539) were examined in 464 schizophrenics and 464 healthy controls from Hunan province in South China, using the Sequenom MassARRAY® iPLEX System.

Results: In the study population, rs520688 and rs2030324 were significantly associated with schizophrenia.

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Objective: To analyze the clinical features, treatments and prognosis of patients with Sister Mary Joseph's nodule of umbilicus (SMJN) from epithelial ovarian cancer (EOC) patients.

Methods: Among a total of 2642 pathologically diagnosed EOC cases, 21 cases with SMJN were histopathologically diagnosed and had an age range of 40-66 years at Sun Yat-sen University Cancer Center between January 1991 and January 2011. Their clinical data were retrospectively analyzed.

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Aims: Small-cell carcinoma is a variant of poorly differentiated neuroendocrine carcinoma. Primary small-cell carcinoma of the cervix (SCCC) is recognised as a rare and aggressive malignant tumour with poor prognosis. In this study, the authors report 25 Chinese cases of SCCC, with a particular focus on their clinical and pathological characteristics.

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Objective: To evaluate the clinical pathological characteristics, treatment and prognosis of ovarian carcinosarcoma.

Methods: The clinical, pathological and follow-up data of 12 cases of ovarian carcinosarcoma treated in Cancer Center of Sun Yat-sen University from May, 2002 to May, 2009 were analyzed retrospectively.

Results: The 12 patients with ovarian carcinosarcoma had a median age of 55 years at diagnosis, among whom 10 were postmenopausal women.

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The effects of pH and Cu2+ on the detection of the Microcystin-LR based on evanescent wave all-fiber immunosensor (EWAI) and their elimination were studied. The experimental results indicated that both low pH and high pH greatly affected the immunoassay results of MC-LR. When pH was less than 6 or higher than 8, the fluorescence signals detected by immunosensor system obviously reduced with the decrease or increase of pH.

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  • * Results showed that pH levels greatly impacted fluorescence signals, with optimal detection occurring between pH 6 and 8; outside this range, signals weakened significantly.
  • * Low levels of Cu(2+) had minimal impact on detection, but concentrations above 5 mg/L caused a notable decrease in fluorescence, which could be corrected by adding EDTA during the pre-reaction process.
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The evanescent wave fluorescence immunosensor, which employs evanescent wave produced in interface of the waveguide when the light transmits on the manner of total internal reflection in the waveguide, is relatively new kind of sensor on the basis of fluorescence immunoassay principle. This sensor has many advantages including strong specificity, high sensitivity, rapid detection, cost-effective and simple operation, which will be widely applied for environmental detection, clinical medicine and food industry. The principle, structure and characteristics of evanescent wave fluorescence immunosensors were covered and the applications of this kind of sensor in environmental detection were introduced.

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With reference to a control system operating under same conditions, unstirred dead-end NF processes of magnetic pretreated solution containing Ca2+ were conducted with NF and NF270 nanofiltration membranes to study the influence of magnetic field on the membrane flux and the crystallization of CaCO3 on membrane surface. Ca2+ in the solution was 3.6 mmol/L, and the hardness was equal to the alkalinity.

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