Co-adaption of tRNA gene copy number and amino acid usage influences translation rates in three life domains.

Although more and more entangled participants of translation process were realized, how they cooperate and co-determine the final translation efficiency still lacks details. Here, we reasoned that the basic translation components, tRNAs and amino acids should be consistent to maximize the efficiency and minimize the cost. We firstly revealed that 310 out of 410 investigated genomes of three domains had significant co-adaptions between the tRNA gene copy numbers and amino acid compositions, indicating that maximum efficiency constitutes ubiquitous selection pressure on protein translation.

Predicting subcellular localization of mycobacterial proteins by using Chou's pseudo amino acid composition.

The successful prediction of protein subcellular localization directly from protein primary sequence is useful to protein function prediction and drug discovery. In this paper, by using the concept of pseudo amino acid composition (PseAAC), the mycobacterial proteins are studied and predicted by support vector machine (SVM) and increment of diversity combined with modified Mahalanobis Discriminant (IDQD). The results of jackknife cross-validation for 450 non-redundant proteins show that the overall predicted successful rates of SVM and IDQD are 82.

A novel mutation in EXT2 gene in a Chinese family with hereditary multiple exostoses.

Hereditary multiple exostoses (HME) is an autosomal-dominant disorder characterized by the presence of bony outgrowths on the long bones. In this report, we describe a Chinese family with HME. Linkage analysis and mutation detection were performed.

[Temperature dependence study of calf thymus DNA by Raman spectra].

In this paper, the authors obtained Raman spectra of DNA in fiber and aqueous solution at different temperatures. These spectra revealed that the vibration of bases and phosphate group were influenced by varying temperature. Adenine was the most sensitive to varying temperature in all of the vibrational modes.