Identification of ginsenoside metabolites in plasma related to different bioactivities of Panax notoginseng and Panax ginseng.

Although the chemical components of Panax notoginseng (PN) and Panax ginseng (PG) are similar, their bioactivities are different. In this study, the differential bioactivities of PN and PG were used as the research object. First, the different metabolites in the plasma after oral administration of PN and PG were analyzed using a UPLC-Q/TOF-MS-based metabolomics approach.

Effect of humic acid as a photosensitizer combined with low-energy laser on orthodontic tooth movement in rats.

Background/purpose: Humic acid (HA) could promote light conversion reaction, and lasers accelerate orthodontic tooth movement. We investigated the effect of HA, as a photosensitizer, combined with low-energy laser on orthodontic tooth movement in rats.

Materials And Methods: An orthodontic tooth movement model was established, and the upper left first molar was moved mesially by a nickel-titanium tension spring with a 50-g force.

Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure.

Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and morphology maintenance characteristics, and be optimized as a micro unit for cartilage tissue engineering. Chondro-spheroids were loaded into a cross-linkable hybrid hydrogel of gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA) in vivo and in vitro.

Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults.

Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer's disease (AD). Evidence for these associations during the preclinical stages of AD, when Aβ and tau pathologies first become detectable, is mixed.

Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies.

Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI and FET-PET scans.

Occupational Well-Being in Beginning Early Childhood Educators of Hong Kong and the Prediction of Job-Related Factors: Variable-Centered and Person-Centered Approaches.

The occupational well-being (OWB) of early childhood educators (ECEs) play a crucial role in their job performance, the development of a child, and the operation of early childhood education sectors. OWB of ECEs has been an increasing concern in recent years and this concern might be particularly salient for beginning ECEs given the multiple adaptive changes and challenges they encounter during the transition from training to teaching. However, research on the beginning ECEs' OWB has been scarce.

The Signaling Pathway of PGE and Its Regulatory Role in T Cell Differentiation.

Prostaglandin E2 (PGE) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 and CD8 T cell subsets, play crucial roles in the adaptive immune response.

LncRNA HOTTIP from synovial fibroblast-derived exosomes: A novel molecular target for rheumatoid arthritis through the miR-1908-5p/STAT3 axis.

Rheumatoid arthritis (RA) is a chronic inflammation mediated by autoimmune responses. HOTTIP, a long noncoding RNA (lncRNA), participates in cell proliferation and invasion. However, the correlation between HOTTIP and RA remains unclear.

Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling.

Laron syndrome (LS) is an autosomal recessive genetic disease mainly caused by mutations in the human growth hormone receptor () gene. Previous studies have focused on mutant mice, but compared with LS patients, knockout (KO) mice exhibit differential lipid metabolism. To elucidate the relationship between mutation and lipid metabolism, the role of GHR in lipid metabolism was examined in KO pigs and hepatocytes transfected with si.

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis.

Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear. The PubMed, Embase, and Cochrane Library databases were searched.

A brain proteomic signature of incipient Alzheimer's disease in young ε4 carriers identifies novel drug targets.

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer’s disease (AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean age, 89 ± 9 years). A subset of these proteins was also differentially abundant in the brains of young ε4 carriers relative to noncarriers (mean age, 39 ± 6 years). Several of these proteins represent targets of approved and experimental drugs for other indications and were validated using orthogonal methods in independent human brain tissue samples as well as in transgenic AD models.

Music in Noise: Neural Correlates Underlying Noise Tolerance in Music-Induced Emotion.

Music can be experienced in various acoustic qualities. In this study, we investigated how the acoustic quality of the music can influence strong emotional experiences, such as musical chills, and the neural activity. The music's acoustic quality was controlled by adding noise to musical pieces.

Palladium-catalyzed C-H glycosylation and retro Diels-Alder tandem reaction structurally modified norbornadienes (smNBDs).

This report describes palladium-catalyzed C-H glycosylation and retro Diels-Alder tandem reaction structurally modified norbornadienes (smNBDs). smNBDs were proposed to regulate the reactivity of the aryl-norbornadiene-palladacycle (ANP), including its high chemoselectivity and regioselectivity, which were the key to constructing C2 and C3 unsubstituted C4-glycosidic indoles. The scope of this substrate is extensive; the halogenated six-membered and five-membered glycosides were applied to the reaction smoothly, and -alkyl (primary, secondary and tertiary) C4-glycosidic indoles can also be obtained by this method.

Identification of metabolites in plasma related to different biological activities of Panax ginseng and American ginseng.

Rationale: Panax ginseng (PG) and American ginseng (AMG) are both medicinal plants of the Panax genus in the Acanthopanax family. Although PG and AMG have similar components of ginsenosides, there are many differences of their bioactivities. In this study, the biochemical mechanisms of different bioactivities of PG and AMG were explored by researching the differential metabolites in plasma after administration of each of PG and AMG.

Cathepsin C Is Involved in Macrophage M1 Polarization via p38/MAPK Pathway in Sudden Cardiac Death.

This study was aimed at identifying molecular markers associated with the pathogenesis of sudden cardiac death (SCD). It provides a proteomic analysis of human left anterior descending coronary artery from subjects diagnosed with SCD through histological examination and cases of nondisease accidental deaths through autopsy. A total of 2784 proteins were obtained from label-free quantitative proteomic analysis.

Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.

Background: Higher energetic costs for mobility are associated with declining gait speed, and slow gait is linked to cognitive decline and Alzheimer's disease. However, the physiological underpinnings of gait and brain health have not been well explored. We examined the associations of the energetic cost of walking with brain volume in cognitively unimpaired adults from the Baltimore Longitudinal Study of Aging.

The Application of Cartilage Tissue Engineering with Cell-Laden Hydrogel in Plastic Surgery: A Systematic Review.

Background: As a contour-supporting material, the cartilage has a significant application value in plastic surgery. Since the development of hydrogel scaffolds with sufficient biomechanical strength and high biocompatibility, cell-laden hydrogels have been widely studied for application in cartilage bioengineering. This systematic review summarizes the latest research on engineered cartilage constructed using cell-laden hydrogel scaffolds in plastic surgery.

Palladium-Catalyzed C-H Amination/[2 + 3] or [2 + 4] Cyclization via C(sp or sp)-H Activation.

This report describes a palladium-catalyzed Catellani reaction consisting of amination/[2 + 3] or [2 + 4] cyclization via a carboxylate ligand-exchange strategy. This method effectively activates -substituents that avoid a second C-H palladation. The scope of substrates was broad, -methyl-substituted iodoarenes were applied to the reaction smoothly, and -phenyl-substituted iodoarenes can also be obtained by this method.

Identification of key genes in osteosarcoma - before and after CDK7 treatment.

Background: Osteosarcoma is one of the most common bone tumors, with a high degree of malignancy and a poor prognosis. Recent studies have shown that THZ2, a cyclin-dependent kinase 7 inhibitor, can exhibit strong antibone tumor effects in vivo and in vitro by inhibiting transcriptional activity. In this study, by screening the differentially expressed genes (DEGs) of osteosarcoma cells before and after THZ2 treatment, it provides new possible targets for the future targeted therapy of osteosarcoma.

Realize Emergent Gravity to Generic Situations.

We clarify the problem in which occasions can gravitational force be regarded emergent from thermodynamics, by proposing an entropic mechanism that can extract the entropic gradient existing in spacetime, due to the variation of the Casini-Bekenstein bound in specific quasi-static processes with the heat flux into the whole casual wedge. We explicitly formulate the derivation of inertial force as the emergent gravitational attraction from the Entanglement First Law. We find the saturation of the bound along with the vanishing relative entropy corresponds to the variation of minimal surface.

Helicopter parenting and depressive level among non-clinical Chinese college students: A moderated mediation model.

Background: Helicopter parenting has been one of major contributing factors to depression, and the occurrence of severe depressive level has been increasing in college students. Based on self-determinant theory (SDT), previous studies have indicated the pathway between helicopter parenting and depressive level, especially focusing on the roles of basic psychological needs, self-control and teacher autonomy support. But few studies focused on the full model of these interactive factors and the Chinese non-clinical college students.

Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.

Introduction: Higher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown.

Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.

Colorectal signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer (CRC) with unique characteristics. Due to the limited researches on it, a comprehensive and in-depth understanding of this subtype is still lacking. In this article, we summarize the clinicopathological features and molecular characteristics of colorectal SRCC based on a literature review.