Biodetoxification of both AFB1 and ZEN by Bacillus subtilis ZJ-2019-1 in gastrointestinal environment and in mice.

Aflatoxin B1 (AFB1) and zearalenone (ZEN) are the most prevalent mycotoxins in production, posing a serious threat to human and animal health. Therefore, it is very urgent to find a safe and efficient method for the biodegradation of these mycotoxins. Our previous study demonstrated that Bacillus subtilis ZJ-2019-1 moderately degrades both mycotoxins in vitro and ZEN in female gilts.

Nationwide prediction of pesticide residual levels in soil: Implications on the resulting risk and prioritization framework.

Pesticides are widely accumulated in agricultural soils in China under successive applications, causing negative impacts on non-target species and environmental qualities. However, a nationwide overview of the residual levels of pesticides in soil, and the ecological risks to non-target soil species are lacking. In this study, we calculated geographically gridded concentrations of 107 pesticide active ingredients (AIs) in soils in China based on the Computational Pesticide Input (CPI) model and further assessed the ecological risks to soil biota.

Visible-Thermal Tiny Object Detection: A Benchmark Dataset and Baselines.

Visible-thermal small object detection (RGBT SOD) is a significant yet challenging task with a wide range of applications, including video surveillance, traffic monitoring, search and rescue. However, existing studies mainly focus on either visible or thermal modality, while RGBT SOD is rarely explored. Although some RGBT datasets have been developed, the insufficient quantity, limited diversity, unitary application, misaligned images and large target size cannot provide an impartial benchmark to evaluate RGBT SOD algorithms.

Specific detection of Brucella spp. from slaughter-aged livestock using a dual priming oligonucleotide system.

Background: Brucella spp. are Gram-negative bacteria causing brucellosis, a major zoonotic disease affecting animals and humans. Annually, over 500,000 human cases are reported globally, with many undiagnosed due to nonspecific symptoms and diagnostic challenges.

High-quality genome of black wolfberry ( Murr.) provides insights into the genetics of anthocyanin biosynthesis regulation.

Black wolfberry ( Murr.) is an important plant for ecological preservation. In addition, its fruits are rich in anthocyanins and have important edible and medicinal value.

Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds.

Accurate prediction of liquid chromatographic retention times is becoming increasingly important in nontargeted screening applications. Traditional retention time approaches heavily rely on the use of standard compounds, which is limited by the speed of synthesis and manufacture of standard products, and is time-consuming and labor-intensive. Recently, machine learning and artificial intelligence algorithms have been applied to retention time prediction, which show unparalleled advantages over traditional experimental methods.

A sarcopenia prediction model based on the calf maximum muscle circumference measured by ultrasound.

Background: The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the correlation between calf maximum muscle circumference (CMMC) measured by ultrasound and sarcopenia has not been reported. We aims to construct a predictive model for sarcopenia based on CMMC in hospitalized older patients.

Methods: This was a retrospective controlled study of patients > 60 years of age hospitalized in the geriatric department of Hunan Provincial People's Hospital.

Synthesis of a Bimetallic-Doped Phytate-Melamine Composite as an Efficient Additive for Epoxy Resins with High Fire Safety.

The issue of hazardous smoke and toxic gases released from epoxy resins (EP), which often causes casualties in real fires, has limited its application. Therefore, we have developed a novel flame retardant based on a bimetallic-doped phytate-melamine (BPM) structure with Zn and Fe ions incorporated into the polymer matrix using a straightforward solution-based synthetic method. The combustion performance of the composite was evaluated using a cone calorimeter test, which showed that the peak heat release, total heat release, and total smoke production were reduced by 50%, 31.

Vanillin Has Potent Antibacterial, Antioxidant, and Anti-Inflammatory Activities In Vitro and in Mouse Colitis Induced by Multidrug-Resistant .

A large number of cases of infectious colitis caused by multidrug-resistant (MDR) bacteria, such as , can result in colon damage and severe inflammation. Vanilla, a widely utilized flavor and fragrance compound, is extensively used in various food. However, the effect of vanilla on MDR -induced infectious colitis has received less attention.

Machine Learning for Predicting Zearalenone Contamination Levels in Pet Food.

Zearalenone (ZEN) has been detected in both pet food ingredients and final products, causing acute toxicity and chronic health problems in pets. Therefore, the early detection of mycotoxin contamination in pet food is crucial for ensuring the safety and well-being of animals. This study aims to develop a rapid and cost-effective method using an electronic nose (E-nose) and machine learning algorithms to predict whether ZEN levels in pet food exceed the regulatory limits (250 µg/kg), as set by Chinese pet food legislation.

The Implementation of Perioperative Geriatric Management Could Decrease the Incidence of Postoperative Delirium in the Elderly Undergoing Major Orthopedic Surgeries.

Objectives: This study aimed to explore the association of perioperative geriatric management (PGM) in major orthopedic surgeries.

Methods: One hundred seventy-five participants aged 75 and older were in-hospital patients who underwent major orthopedic surgery from September 2020 to September 2021, and they received PGM and necessary treatment for indicators with abnormal value (the PGM group). Another 175 participants in the control group only received the evaluation part of the PGM, recruited by filtering in the electronic medical record system from March 2016 to March 2017.

Preparation and Application of a Urea-Formaldehyde-Blended Guanidinium Azole-Phytic Acid-Copper Flame-Retardant Resin Coating.

In this study, environmentally friendly flame retardants capable of efficient flame retardancy at low concentrations in wood were developed. Urea-formaldehyde (UF) resin and guanidinium azole (GZ)-phytate (PA)-copper hydroxide (Cu(OH)) flame-retardant resin coating blends were prepared using urea, formaldehyde, 3,5-diamino-1,2,4-triazole (GZ), phytanic acid (PA), and copper hydroxide (Cu(OH)). Employing dioctyl phthalate as the plasticizer and tannic acid as the curing agent, a three-stage reaction was performed to obtain the desired UF-GZ/PA/Cu as a bio-based flame retardant.

Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma.

Cholangiocarcinoma remains a challenging primary hepatobiliary malignancy with dismal prognosis. Photodynamic therapy (PDT),a less invasive treatment, has been found to inhibit the proliferation and induce ferroptosis, apoptosis and necrosis in other tumor cells in recent years. Regrettably, the role and exact molecule mechanism of PDT is still incompletely clear in cholangiocarcinoma cells.

Risk factors of allergic rhinitis and its prevention strategies.

Allergic rhinitis (AR) is a global disease with high prevalence. It reduces the patient's quality of life seriously. The health care and management of AR was also a heavy social burden.

Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic Steatosis.

Background & Aims: Crotonylation (Kcr), a newly identified post-translation modification (PTM), has been confirmed to be involved in diverse biological processes and human diseases as well. Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a serious threat to people's health. Augmenter of liver regeneration (ALR) is an important liver regulatory protein, and the insufficiency of ALR expression is reported to accelerate liver steatosis progression to liver fibrosis or even hepatic carcinoma (HCC).

The Molecular Cloning and Functional Analysis of the Gene in L.

Seabuckthorn ( Linn.) is a commonly utilized medicinal crop with various applications in the treatment of different diseases. Two particularly noteworthy nutrients in seabuckthorn fruit are seabuckthorn oil and flavonoids.

The different impacts of functional network centrality and connectivity on the complexity of brain signals in healthy control and first-episode drug-naïve patients with major depressive disorder.

In recent years, brain signal complexity has gained attention as an indicator of brain well-being and a predictor of disease and dysfunction. Brain entropy quantifies this complexity. Assessment of functional network centrality and connectivity reveals that information communication induces neural signal oscillations in certain brain regions.

Evaluating the effects of silent genes on pairwise kinship testing.

Short tandem repeat (STR) loci are frequently utilized in kinship testing, and mutations of a single base occurring in the primer-binding region of the STR locus can result in the failure of allelic amplification and the emergence of silent genes. Silent genes are not observable and, therefore, are excluded from the genotypes assessed. Pedigree likelihood ratios (LRs) are often employed in kinship testing to determine the likelihood of different kinship scenarios.

Simultaneous occurrence of thyroblastoma and papillary carcinoma.

Not required for Clinical Vignette.

Cyberbullying Victimization and Perpetration in Adolescents: A Longitudinal Moderated Mediation Model.

Although cyberbullying victimization significantly impacts cyberbullying behaviors, research on its longitudinal mechanisms and protective factors remains scarce. A total of 1465 Chinese adolescents (52.2% female) with an average age of 16.

Simultaneous Degradation of AFB1 and ZEN by CotA Laccase from ZJ-2019-1 in the Mediator-Assisted or Immobilization System.

The global prevalence of aflatoxin B1 (AFB1) and zearalenone (ZEN) contamination in food and feed poses a serious health risk to humans and animals. Recently, enzymatic detoxification has received increasing attention, yet most enzymes are limited to degrading only one type of mycotoxin, and free enzymes often exhibit reduced stability and activity, limiting their practicality in real-world applications. In this study, the laccase gene from ZEN/AFB1-degrading ZJ-2019-1 was cloned and successfully expressed in BL21, achieving a protein yield of 7.

Allergies to Allergens from Cats and Dogs: A Review and Update on Sources, Pathogenesis, and Strategies.

Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms, such as rhinitis and asthma, in humans. With the increasing popularity of and care provided to these companion animals, the allergens they produce pose a growing threat to susceptible patients' health. Allergens from cats and dogs have emerged as significant risk factors for triggering asthma and allergic rhinitis worldwide; however, there remains a lack of systematic measures aimed at assisting individuals in recognizing and preventing allergies caused by these animals.