Publications by An Phu Tran Nyguyen

Publications by authors named "An Phu Tran Nyguyen"

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Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA.

Matthias Corrotte An Phu Tran Nyguyen Marie Line Harlay Nicolas Vitale Marie-France Bader

J Immunol

September 2010

Phagocytosis is an essential element of the immune response permitting the elimination of pathogens, cellular debris, apoptotic cells, and tumor cells. Recently, both phospholipase D (PLD) isoforms, PLD1 and PLD2, were shown to be necessary for efficient FcgammaR-mediated phagocytosis. In this study, we investigated the role of a potential PLD regulator, the Ral GTPases RalA and RalB, in murine RAW 264.

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- An Phu Tran Nyguyen's research primarily focuses on the molecular mechanisms underlying phagocytosis, specifically the role of Ral GTPases in regulating phospholipase D (PLD) isoforms during Fc gamma receptor-mediated phagocytosis.
- The findings indicate that RalA and RalB, by influencing PLD1 and PLD2 activity, are crucial for efficient immune response through phagocytosis, highlighting their potential as regulatory factors in immune cell function.
- This work contributes to a deeper understanding of how cells eliminate pathogens and apoptotic cells, which is essential for developing therapeutic strategies targeting immune responses.

Publications by authors named "An Phu Tran Nyguyen"

Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA.

Synopsis of recent research by authors named "An Phu Tran Nyguyen"