Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of to antimicrobial peptide Brevinin-2CE.

The response of ATCC8739 to Brevinin-2CE (B2CE) was evaluated as a strategy to prevent the development of antimicrobial peptide (AMP)-resistant bacteria. Gene expression levels were detected by transcriptome sequencing and RT-PCR. Target genes were knocked out using CRISPR-Cas9.