BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression.

Background: Papillary thyroid carcinoma (PTC) is a common malignant tumor. BRAF mutation has become a common molecular event in PTC pathogenesis. Circular RNA PSD3 (circPSD3) is known to be highly expressed in PTC.

Enhanced detection of glutamate via transverse relaxation encoding with narrowband decoupling in the human brain.

Purpose: This study aims to improve the detection of glutamate (Glu) concentration and T using an enhanced transverse relaxation encoding with narrowband decoupling (TREND) technique.

Methods: A new editing pulse was designed to simultaneously invert both Glu H3 spins (2.12 ppm and 2.

Effect of photobiological regulation of green laser on orthodontic tooth retention in rats.

Green lasers have a stronger effect on promoting osteoblast differentiation, which is critical for orthodontic tooth retention. This study investigated the impact of green laser photobiomodulation on orthodontic tooth retention in rats. A total of 100 male Sprague-Dawley rats were divided into two groups: Group A (control) and Group B (green laser irradiation).

Comprehensive multi-omics analysis reveals the mechanism of hepatotoxicity induced by Emilia sonchifolia (L.) DC.

Ethnopharmacological Relevance: Emilia sonchifolia is a very widely used traditional Chinese medicine, with the efficacy of heat-clearing, detoxicating, dissipating blood stasis, reducing swelling and relieving pain. As a widely used traditional miao herb, Emilia sonchifolia is often used to treat upper respiratory tract infections, oral ulcer, pneumonia, mastitis, enteritis, bacillum, urinary tract infection, sores, eczema, falls and injuries, etc. In fact, many cases of liver injury caused by Emilia sonchifolia have been reported clinically.

Transcriptome, miRNA, and degradome sequencing reveal the leaf stripe (Pyrenophora graminea) resistance genes in Tibetan hulless barley.

Barley leaf stripe, a disease mainly caused by Pyrenophora graminea (P. graminea) infection, severely affects barley yield and quality and is one of the most widespread diseases in barley production. However, little is known about the underlying molecular mechanisms of leaf stripe resistance.

Research on the PFAS release and migration behavior of multi-layer outdoor jacket fabrics.

Perfluoroalkyl and poly-fluoroalkyl substances (PFAS) release from textiles is a source of human exposure, but the mechanisms behind this release remain insufficiently studied. This research investigates the release and transport mechanisms of PFAS in outdoor jacket fabrics treated with a short side-chain fluorinated polymers (CF-SFPs) for durable water repellency (DWR). PA-based and PET-based fabrics were exposed to outdoor conditions and subjected to accelerated aging, followed by abrasion, washing, and drying experiments to simulate wear and degradation.

Genetic alterations and their prognostic impact in marginal zone lymphoma: a meta-analysis.

This meta-analysis aimed to assess the impact of genetic mutations, particularly in the NOTCH2 and TNFAIP3 genes, on the prognostic outcomes of Marginal Zone Lymphoma (MZL) patients. Databases, including PubMed, Embase, and Cochrane Library, were explored up to October 2023. A total of 11 studies encompassing 2,314 records were included.

Prophylactic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for low-grade appendiceal mucinous tumors with early and limited disease after completely removed.

The necessity of prophylactic cytoreductive surgery (PCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for low-grade appendiceal mucinous neoplasms (LAMN) after complete removal is still controversial. This study aims to determine the role of PCRS + HIPEC and identify optimal strategies for managing these patients. One hundred fifty-nine patients who sought medical advice at Aerospace Center Hospital were retrospectively analyzed from January 2011 to December 2021.

Unraveling the complexity of follicular lymphoma: insights and innovations.

This review discusses multiple aspects of follicular lymphoma (FL), including etiology, treatment challenges, and future perspectives. First, we delve into the etiology of FL, which involves a variety of pathogenic mechanisms such as gene mutations, chromosomal abnormalities, immune escape, immune system dysregulation, familial inheritance, and environmental factors. These mechanisms provide the context for understanding the diversity and complexity of FL.

Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function.

There are no therapies for reversing chronic organ degeneration. Non-healing degenerative wounds are thought to be irreparable, in part, by the inability of the tissue to respond to reparative stimuli. As such, treatments are typically aimed at slowing tissue degeneration or replacing cells through transplantation.

Intravenous lidocaine decreased oxygen-desaturation episodes induced by propofol-based sedation for gastrointestinal endoscopy procedures: a prospective, randomized, controlled trial.

Background: As a popularly used analgesic adjuvant, intravenous (IV) lidocaine could reduce the consumption of propofol in painless gastrointestinal (GI) endoscopy. However, whether IV lidocaine could affect the incidence of oxygen-desaturation episodes (ODE) during painless GI endoscopy is still unknown. Therefore, we tested the hypothesis that IV lidocaine could decrease the incidence of propofol-induced ODE and involuntary movements in patients during GI endoscopy.

Body image research among sexual minority men in the Mekong region: A scoping review.

Body image among sexual minority men (SMM) has received increasing attention. However, the current literature has primarily focused on white SMM and body image and physical appearance concerns among SMM. In response to a call for more nuance in understanding how SMM perceive and make sense of their body image in a broader sociocultural context, we conducted a scoping review to examine the extent and nature of body image research among SMM in the Mekong region.

In vivo GABA detection by single-pulse editing with one shot.

Purpose: Two-shot γ-aminobutyric acid (GABA) difference editing techniques have been used widely to detect the GABA H4 resonance at 3.01 ppm. Here, we introduce a single-shot method for detecting the full GABA H2 resonance signal, which avoids contamination from the coedited M macromolecules.

Aqueous extract of Cornus officinalis alleviate NAFLD via protecting hepatocytes proliferation through regulation of the tricarboxylic acid cycle.

Ethnopharmacological Relevance: Cornus officinalis (CO) has been widely used as Chinese herbal medicine and has a good clinical efficacy in liver disease. In particular, it has a significant therapeutic effect on metabolic liver disease. However, systematic pharmacological studies on its hepatoprotective effect on non-alcoholic fatty liver disease (NAFLD) are lacking.

Predicting Curing Distortion in Composite Manufacturing-A Fast and Cost-Efficient Numerical Simulation Method.

The curing distortion is a critical determinant of the quality of integrally manufactured composite structures, playing a pivotal role in the design and fabrication of composite. This paper presents two simplified methods in predicting the curing distortion for large-scale composite aircraft structures manufactured through the autoclave process. Firstly, the refined finite element models of the two simplified methods were developed.

Cumulative Strain and Improvement Mechanisms of Soil Reinforced by Xanthan Gum Biopolymer Under Traffic Loading.

As is widely accepted, cumulative strain and improvement mechanisms of stabilized soil are critical factors for the long-term reliable operation of expressways and high-speed railways. Based on relevant research findings, xanthan gum biopolymer is regarded as a green and environmentally friendly curing agent in comparison to traditional stabilizers, such as cement, lime, and fly ash. However, little attention has been devoted to the cumulative strain and improvement mechanisms of soil reinforced by xanthan gum biopolymer under traffic loading.

Proteomic Insights into the Regulatory Mechanisms of the Freezing Response in the Alpine Subnivale Plant .

Freezing temperatures impose significant constraints on plant growth and productivity. While cold tolerance mechanisms have been extensively studied in model species, the molecular basis of freezing tolerance in naturally adapted plants remains underexplored. , an alpine plant with a strong freezing tolerance, provides a valuable model for investigating these adaptive mechanisms.

Assessing U.S. public perceptions of global warming using social survey and climate data.

This paper presents a methodological approach for assessing the relationship between weather patterns, regional climate trends, and public perceptions of global warming in the United States with control of socioeconomic, political, and ideological variables. We combined social survey data from the Gallup Poll Social Series (GPSS) with environmental data from the National Oceanic and Atmospheric Administration (NOAA) and the PRISM Climate Group. Logistic regression models were employed, enhanced by Eigenvector Spatial Filtering (ESF) to address spatial autocorrelation.

Xinnaoxin capsule alleviates neuropathological changes and cognitive deficits in Alzheimer's disease mouse model induced by D-galactose and aluminum chloride via reducing neuroinflammation and protecting synaptic proteins.

Ethnopharmacological Relevance: Originally formulated to mitigate high-altitude sickness, Xinnaoxin capsules (XNX) are composed of three traditional Chinese medicines (Rhodiola rosea L., Lycium barbarum L. and Hippophae rhamnoides) with properties of anti-hypoxia, anti-fatigue, and anti-aging.

Risk-based bridge life cycle cost and environmental impact assessment considering climate change effects.

To enhance sustainability and resilience against climate change in infrastructure, a quantitative evaluation of both environmental impact and cost is important within a life cycle framework. Climate change effects can lead performance deterioration in bridge components during their operational phase, highlighting the necessity for a risk-based evaluation process aligned with maintenance strategies. This study employs a two-phase life cycle assessments (LCA) framework.

Ultrasonic optic nerve sheath diameter as a new predictor for the mortality of patients with large hemispheric infarction.

Large hemispheric infarction (LHI) is a severe form of stroke with high mortality and poor outcomes. Ultrasonic optic nerve sheath diameter (ONSD) is considered an effective indicator for intracranial hypertension. Our study aimed to validate the efficiency of ultrasonic ONSD and develop a nomogram to identify LHI patients who have 90-day mortality.

[The Prognostic Predictive Value of mutation Variant Allele Frequency in Diffuse Large B-Cell Lymphoma].

Objective: To explore the effect of mutation variant allele frequency(VAF) on the prognosis of diffuse large B-cell lymphoma(DLBCL) patients.

Methods: This study included 155 patients with DLBCL who were first diagnosed in the People's Hospital of Xinjiang Uygur Autonomous Region from March 2009 to March 2022. Complete clinical data and paraffin-embedded tumor tissue samples were obtained, and DNA was extracted from tumor tissues.

Facilitating microglia M2 polarization alleviates p-Synephrine-induced depressive-like behaviours in CSDS mice via the 5-HT6R-FYN-ERK1/2 pathway.

In recent years, modulation of microglial phenotype transformation has emerged as a promising strategy for treating central nervous system disorders. Aurantii Fructus Immaturus (Zhishi), a traditional Chinese medicine with versatile applications, contains p-Synephrine (p-SYN) as its principal bioactive compound, recognized for its anti-inflammatory efficacy. However, the molecular mechanisms underlying these effects remain unclear.

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.

By targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases. However, most ribose-modified NAs do not present broad-spectrum features, likely due to differences in ribose-RdRP interactions across virus families. Here, we show that HNC-1664, an adenosine analog with modifications both in ribose and base, has broad-spectrum antiviral activity against positive-strand coronaviruses and negative-strand arenaviruses.