Publications by authors named "An Juan"

Tin-based sulfides, possessing a unique layered structure and a high theoretical capacity, stand as highly prospective contenders for anode materials in lithium-ion batteries (LIBs). Nevertheless, the pronounced volume expansion that occurs during lithium storage and poor capacity retention have limited its progress toward commercialization. Herein, we designed and prepared a SnS/RGO composite with a three-dimensional porous structure by sulfurizing the SnO(OH)/GO precursor.

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The treatment of water contaminated with oil or organic solvents has always been a thorny challenge, considering the complexity of water pollution, the susceptibility to secondary pollution and the consequent depletion of resources. Biomass is a versatile, green and self-circulating natural material that shows important potential in designing high-performance oil/water separation materials. This review highlights the recent research progress on biomass-based materials (BBMs) in the field of oil-water separation.

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Traditional linear correlation analysis may not fully capture the true relationship between these variables. Therefore, multi-scale running correlation analysis, such as time-dependent intrinsic correlation (TDIC) and continuous wavelet transform based on Hilbert-Huang transform (HHT), provides valuable insights into local correlations and the evolving relationship between nutrients and environmental factors over time. In this study, we investigated seven environmental factors and four water quality nutrient indicators in deep lakes on the Yungui Plateau in southwestern China.

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Background: Eukaryotic elongation factor 1 alpha 2 (eEF1A2) is a protein coding gene which is involved in tumor development and progression in several types of human cancer, but little is known about the function of eEF1A2 proteins in gastric cancer (GC). This study aimed to investigate the effects of , and on the migration of GC cells.

Methods: The Oncomine and The Cancer Genome Atlas (TCGA) databases were used to evaluate the expression of , , and in GC and the association of eEF1A2 family with individual clinical characteristics.

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Black phosphorus is a two-dimensional layer material with promising applications due to its many excellent physicochemical properties, including high carrier mobility, ambipolar field effect and unusual in-plane anisotropy. Currently, BP has been widely used in biomedical engineering, photocatalysis, semiconductor devices, and energy storage electrode materials. However, the unique structure of BP makes it highly chemically active, leading to its easy oxidation and degradation in air, which limits its practical applications.

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Objective: To investigate the effects of berberine (BBR) as a treatment on intestinal microecological alterations and enteritis in mice produced by TNBS.

Methods: There were seven mice per group: seven in the healthy group (Ctrl), seven in the TNBS-induced enteritis group (TNBS), and seven in the berberine treatment group (BBR). The mice were weighed, slaughtered after 7 days, and subjected to high-throughput intestinal microecological analysis by Illumina, as well as haematological detection and imaging evaluation of colon pathology.

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Background: Patients with programmed cell death-ligand 1 (PD-L1) ≥50% metastatic non-small cell lung cancer (NSCLC) treated with first-line immunotherapy showed heterogeneous tumor responses. In this study, we investigated the clinical and immune-inflammatory markers distinguishing patients with metastatic NSCLC achieving high depth of tumor response (HDPR) from those with non-high depth of response (NHDPR). The impact of clinical features on the prognosis of patients with PD-L1 ≥50% were further clarified.

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Aerospace magnetic material scraps are abundant in cobalt and nickel. Sulfuric acid leaching process is an efficient method for extracting them. But it is a non-selective process, a significant amount of iron dissolves in the solution.

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Article Synopsis
  • - Unique heterostructures enhance potassium (K) storage in transition metal selenides by generating internal electric fields that lower charge transfer activation energy.
  • - The researchers created NiTe/MoS@C heterogeneous interfaces, achieving stable heterojunctions that exhibit special electronic properties due to low lattice misfits and strong electric fields.
  • - The NiTe/MoS@C anode showed excellent performance in potassium-ion batteries, with a reversible capacity of 125.8 mAh/g after 1000 cycles and stable capacity even after extensive cycling, proving its strong applicability in energy storage.
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Background And Objectives: Surface-based facial scanning registration emerged as an essential registration method in the robot-assisted neuronavigation surgery, providing a marker-free way to align a patient's facial surface with the imaging data. The 3-dimensional (3D) structured light was developed as an advanced registration method based on surface-based facial scanning registration. We aspire to introduce the 3D structured light as a new registration method in the procedure of the robot-assisted neurosurgery and assess the accuracy, efficiency, and safety of this method by analyzing the relative operative results.

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Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing. Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-characterized human samples.

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Article Synopsis
  • The study explores how liver cells in mammals coordinate their responses during normal function and when faced with challenges, addressing a significant knowledge gap in understanding liver-related diseases.
  • Researchers used advanced techniques, including Stereo-seq and single-cell transcriptomics, to create a detailed atlas of mouse liver homeostasis and regeneration, analyzing a massive dataset of over 473,000 cells.
  • Key findings include identifying the transcriptional cofactor TBL1XR1, which plays a crucial role in linking inflammation to liver cell proliferation, paving the way for future studies on organ physiology and dysfunction.
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The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase receptor B (TrkB) are widely expressed in the central nervous system. It is well documented that neurons express BDNF and full-length TrkB (TrkB.FL) as well as a lower level of truncated TrkB (TrkB.

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At the center of the hippocampal tri-synaptic loop are synapses formed between mossy fiber (MF) terminals from granule cells in the dentate gyrus (DG) and proximal dendrites of CA3 pyramidal neurons. However, the molecular mechanism regulating the development and function of these synapses is poorly understood. In this study, we showed that neurotrophin-3 (NT3) was expressed in nearly all mature granule cells but not CA3 cells.

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Lithium metal is an attractive and promising anode material due to its high energy density and low working potential. However, the uncontrolled growth of lithium dendrites during repeated plating and stripping processes hinders the practical application of lithium metal batteries, leading to low Coulombic efficiency, poor lifespan, and safety concerns. In this study, we synthesized highly lithiophilic and conductive Ag nanoparticles decorated on SiO nanospheres to construct an optimized lithium host for promoting uniform Li deposition.

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Limited charge separation/transport efficiency remains the primary obstacle of achieving satisfying photoelectrochemical (PEC) water splitting performance. Therefore, it is essential to develop diverse interfacial engineering strategies to mitigate charge recombination. Despite obvious progress having been made, most works only considered a single-side modulation in either the electrons of conduction band or the holes of valence band in a semiconductor photoanode, leading to a limited PEC performance enhancement.

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Objective: Use TCGA data to screen the significantly expressed genes in gastric cancer,then analyze the biological functions of characteristic genes.To identify potential targets for the diagnosis, prognosis and therapeutic monitoring of gastric cancer.

Methods: Download the high-throughput gastric cancer patient tissue mRNA expression data from the TCGA database, and used the edgeR software package to perform gene differences using the Rstudio software according to the |logFC|>1 and p<0.

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Article Synopsis
  • Hypersaline wastewater, which contains over 3.5% salt, poses challenges for biological treatment due to its toxic effects on bacteria, particularly in chlorophenol contamination.
  • Researchers developed a salt-tolerant strain of Rhodococcus rhodochrous, called CP-8, capable of degrading 4-chlorophenol in the presence of 8% NaCl by enhancing its intracellular cAMP levels that improve its growth under osmotic stress.
  • The study also identified a mutant form of an enzyme related to chlorophenol breakdown that showed increased activity, suggesting potential for more effective treatments of hypersaline wastewater.
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Objectives: Clear cell renal cell carcinoma (ccRCC) is a highly prevalent subtype of malignant renal tumor, but unfortunately, the survival rate remains unsatisfactory. The aim of the present study is to explore genomic features that are correlated with cancer stage, allowing for the identification of subgroups of ccRCC patients with high risk of unfavorable outcomes and enabling prompt intervention and treatment.

Methods: We compared the gene expression levels across ccRCC patients with diverse cancer stages from The Cancer Genome Atlas (TCGA) database, which revealed characteristic genes associated with tumor stage.

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Background: The absence of thyroid transcription factor 1 (TTF-1) is associated with a lower frequency of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma (LUAD). The aim of this study was to assess the impact of TTF-1 expression on the clinical response to EGFR-tyrosine kinase inhibitor (TKI) treatment in patients with advanced LUAD.

Methods: The data of patients with advanced LUAD who were admitted to the Beijing Tiantan Hospital and Peking University Cancer Hospital (China) between April 2009 and May 2023 was retrospectively analyzed.

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The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase receptor B (TrkB) are widely expressed in the central nervous system. It is well documented that neurons express BDNF and full-length TrkB (TrkB.FL), and a lower level of truncated TrkB (TrkB.

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Changes in natural rainfall characterized by heavy precipitation and high rainfall intensity would increase the risks and uncertainty of nutrients losses. Losses of nitrogen (N) and phosphorus (P) with water erosion from agriculture-related activities has become the principal nutrients resulting the eutrophication of water bodies. However, a little attention has been paid to the loss characteristic of N and P responding to natural rainfall in widely used contour ridge systems.

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Article Synopsis
  • The study investigates the ecological risks of heavy metal pollution, specifically focusing on the Yellow River estuary, under the water-sediment regulation scheme (WSRS).
  • It was found that Cadmium (Cd) posed a moderate ecological risk, and Suaeda salsa, a wetland plant, showed an increased ability to accumulate Cd with higher concentrations in the water, despite experiencing decreased overall biomass.
  • Additionally, deeper water logging negatively impacted S. salsa's growth and Cd absorption, highlighting the complex interaction between heavy metal input and water conditions in wetland ecosystems.
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Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis, a major cause of morbidity and mortality worldwide. However, there are currently no effective anti-fibrotic therapies available, especially for late-stage patients, which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cell-specific responses in different fibrosis stages. To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes, we generated a single-nucleus transcriptomic atlas encompassing 49 919 nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride (CCl )-induced progressive liver fibrosis.

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