Publications by authors named "AmyJo Koser"
Article Synopsis
- The study addresses the limitations of current Alzheimer's treatments, particularly donepezil and xanomeline, which cause significant gastrointestinal side effects leading to poor patient compliance.
- Researchers tested donepezil, xanomeline, and a new drug called PQCA in rhesus macaques to evaluate their effects on cognition and side effects.
- Results showed that while donepezil and xanomeline caused GI issues at low doses, PQCA showed no such side effects, suggesting it could be a more tolerable and effective option for improving cognitive symptoms in Alzheimer's patients.