Publications by authors named "Amy Shyu"
Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells, and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens. Yet, how other classes of tumour-infiltrating T cells contribute to cancer immunosurveillance remains elusive. Here, in a survey of T cells in mouse and human malignancies, we identified a population of αβ T cell receptor (TCR)-positive FCER1G-expressing innate-like T cells with high cytotoxic potential (ILTCKs).
View Article and Find Full Text PDFAerobic glycolysis-the Warburg effect-converts glucose to lactate via the enzyme lactate dehydrogenase A (LDHA) and is a metabolic feature of effector T cells. Cells generate ATP through various mechanisms and Warburg metabolism is comparatively an energy-inefficient glucose catabolism pathway. Here, we examined the effect of ATP generated via aerobic glycolysis in antigen-driven T cell responses.
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- CD22 serves as an alternative target for immunotherapy in B cell acute lymphoblastic leukemia (ALL), especially after patients relapse from CD19-directed CAR T cell treatments.
- In two pilot clinical trials (NCT02588456 and NCT02650414), researchers evaluated a CD22-targeting CAR T cell using a 4-1BB-based design, focusing on safety and antileukemic efficacy, but found unexpectedly low response rates.
- Further investigation revealed that modifying the CAR's linker led to improved receptor function through autonomous signaling, suggesting that this signaling enhances CAR T cell efficacy and informing the development of a new CAR construct for clinical testing.
Infection triggers expansion and effector differentiation of T cells specific for microbial antigens in association with metabolic reprograming. We found that the glycolytic enzyme lactate dehydrogenase A (LDHA) is induced in CD8 T effector cells through phosphoinositide 3-kinase (PI3K) signaling. In turn, ablation of LDHA inhibits PI3K-dependent phosphorylation of Akt and its transcription factor target Foxo1, causing defective antimicrobial immunity.
View Article and Find Full Text PDFNutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.
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