Publications by authors named "Amy Sarma"

Hypertension in pregnancy contributes substantially to maternal morbidity and mortality, persistent hypertension, and rehospitalization. Hypertensive disorders of pregnancy are also associated with a heightened risk of cardiovascular disease, and timely recognition and modification of associated risk factors is crucial in optimizing long-term maternal health. During pregnancy, there are expected physiologic alterations in blood pressure (BP); however, pathophysiologic alterations may also occur, leading to preeclampsia and gestational hypertension.

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This report discusses the case of a 57-year-old woman with a history of breast cancer and gastric cancer, germline CDH1 gene mutation, who presented to the hospital with syncope. Diagnostic workup revealed a mass in the right ventricular outflow tract. Transcatheter biopsy suggested papillary fibroelastoma, which was confirmed with surgical pathology.

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Article Synopsis
  • Despite progress in recognizing and diagnosing spontaneous coronary artery dissection (SCAD) in the last decade, there is still limited understanding of its mechanisms, contributing factors, and effective treatments.
  • The text highlights research gaps in SCAD and suggests strategies like patient advocacy, independent registries, and specialized centers to improve clinical care and research outcomes.
  • Additionally, it presents a patient-centered clinical care and research framework developed by the SCAD Alliance and International SCAD registry as a model to enhance understanding and management of this condition.
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  • Peripartum cardiomyopathy (PPCM) is a pregnancy-related heart failure linked with preeclampsia, and they may share a common biological cause triggered by factors in late pregnancy.
  • Researchers found that the senescence-associated secretory phenotype (SASP), indicating cellular aging, is significantly activated in women with PPCM or preeclampsia, particularly noting activin A's role in heart dysfunction severity.
  • In studies involving mice, blocking activin A signaling improved heart function postpartum, and using the senolytic compound fisetin during late pregnancy helped enhance cardiac performance, highlighting the connection between aging cells and heart issues during pregnancy.
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  • Preeclampsia is a pregnancy-related condition characterized by high blood pressure and a disruption in the balance of certain proteins, potentially leading to cardiovascular risks due to microvascular dysfunction.
  • Researchers compared cardiac function in women with severe preeclampsia to those with normal pregnancies and nonpostpartum controls using advanced imaging techniques to assess myocardial flow and resistance.
  • Results indicated that women who had preeclampsia showed significantly decreased blood flow and increased vascular resistance, highlighting reduced coronary microvascular function soon after delivery, which could have long-term health implications.
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  • Preeclampsia is a pregnancy-related condition characterized by high blood pressure and microvascular dysfunction, potentially increasing cardiovascular risks post-pregnancy.
  • A study compared women with severe preeclampsia to those with normal pregnancies and non-postpartum controls using cardiac imaging to assess heart function and blood flow.
  • Results showed that women who experienced preeclampsia had significantly reduced heart function and increased vascular resistance, indicating potential long-term cardiovascular issues, warranting further investigation for preventive measures.
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Maternal Cardiovascular Health Post-DobbsPregnancy is associated with increasing morbidity and mortality in the United States. In the post-Dobbs era, many pregnant patients at highest risk no longer have access to abortion, which has been a crucial component of standard medical care.

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Maternal mortality rates are rising in the United States, a trend which is in contrast to that seen in other high-income nations. Cardiovascular disease and hypertensive disorders of pregnancy are consistently the leading causes of maternal mortality both in the United States and globally, accounting for about one-quarter to one-third of maternal and peripartum deaths. A large proportion of cardiovascular morbidity and mortality stems from acquired disease in the context of cardiovascular risk factors, which include obesity, pre-existing diabetes and hypertension, and inequities in care from maternal care deserts and structural racism.

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Article Synopsis
  • Hypertensive disorders of pregnancy (HDPs), such as gestational hypertension and preeclampsia, significantly increase risks of maternal health issues and long-term cardiovascular disease across the globe.
  • The study aimed to link specific proteins in the blood to HDPs using genetic data, employing two-sample mendelian randomization for analysis.
  • Findings involved a broad dataset, including over 393,000 women for gestational hypertension and nearly 607,000 for preeclampsia, uncovering associations between 90 candidate cardiovascular-related proteins and these hypertensive disorders.
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Objective: Greater parity has been associated with cardiovascular disease risk. We sought to find whether the effects on cardiac remodeling and heart failure risk are clear.

Methods: We examined the association of number of live births with echocardiographic measures of cardiac structure and function in participants of the Framingham Heart Study (FHS) using multivariable linear regression.

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The European Association of Percutaneous Cardiovascular Interventions (EAPCI), the European Heart Rhythm Association (EHRA), the European Association of Cardiovascular Imaging (EACVI), the European Society of Cardiology (ESC) Regulatory Affairs Committee and Women as One support continuous review and improvement, not only in the practice of assuring patients a high quality of care but also in providing health professionals with support documents to help them in their career and enhance gender equity. Recent surveys have revealed that radiation exposure is commonly reported as the primary barrier for women pursuing a career in interventional cardiology or cardiac electrophysiology (EP). The fear of foetal exposure to radiation during pregnancy may lead to a prolonged interruption in their career.

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Cardiac biomarkers are widely used in the nonpregnant population when acute cardiovascular (CV) pathology is suspected; however, the behavior of these biomarkers in the context of pregnancy is less well understood. Pregnant individuals often have symptoms that mimic those of cardiac dysfunction, and complications of pregnancy may include CV disease. This paper will summarize our current knowledge on the use of cardiac biomarkers in pregnancy and provide suggestions on how to use these tools in clinical practice based on the available evidence.

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Objective: Whether biomarkers may enable early identification of women who develop peripartum cardiomyopathy (PPCM) prior to disease onset remains a question of interest.

Study Design: A retrospective nested case-control study was conducted to determine whether first trimester -terminal pro-B type natriuretic peptide (NT-proBNP) or high sensitivity cardiac troponin I (hs-cTnI) differed among women who developed PPCM versus unaffected pregnancies. Cases were matched to unaffected women by age, race, parity, and gestational age of sample (control A) and then further by blood pressure and pregnancy weight gain (control B).

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Background: Maternity leave is highly variable in the United States given the lack of a federal workforce mandate.

Objectives: The purpose of this study was to describe the experiences and impact of childbearing on women cardiologists and their careers, within a legal framework.

Methods: A survey was sent to women cardiologists, asking about their experiences while pregnant and on maternity leave.

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Importance: A growing body of evidence suggests that adverse pregnancy outcomes (APOs), including hypertensive disorders of pregnancy, gestational diabetes (GD), preterm birth, and intrauterine growth restriction, are associated with increased risk of cardiometabolic disease and cardiovascular disease (CVD) later in life. Adverse pregnancy outcomes may therefore represent an opportunity to intervene to prevent or delay onset of CVD. The objective of this review was to summarize the current evidence for targeted postpartum interventions and strategies to reduce CVD risk in women with a history of APOs.

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Although some progress has been made in the last 3 decades to increase the number of women in clinical cardiology trials, review of recent cardiovascular literature demonstrates that women and underrepresented minority women are still underrepresented in most clinical cardiology trials. This is especially notable in trials of patients with coronary artery disease, heart failure with reduced ejection fraction, and arrhythmia studies, especially those involving devices and procedures. Despite the call from National Institutes of Health, Food and Drug Administration, Institute of Medicine, and various professional societies, the gap remains.

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