Publications by authors named "Amy McKeown"
Article Synopsis
- Rathke's cleft cyst (RCC) is a benign cyst that usually goes unnoticed but can be associated with rare cases of hyponatremia due to inappropriate antidiuretic hormone (SIADH) secretion.
- The case study discusses a 56-year-old woman who experienced symptoms like blurry vision and headaches, ultimately diagnosed with euvolemic hyponatremia linked to RCC, which was treated effectively via endoscopic surgery.
- The article emphasizes the need for careful evaluation and a multidisciplinary approach in managing such rare instances, while calling for more research to enhance understanding and treatment strategies for RCC related to SIADH.
Article Synopsis
- - The study explores the use of temporoparietal fascial flaps (TPFFs) and vascularized peri cranial flaps (PCFs) as a novel treatment to improve the delivery of therapies for glioblastoma (GBM) by bypassing the constraints of the blood-brain barrier (BBB).
- - A Phase I clinical trial involving 12 patients who underwent GBM surgery assessed the safety of this approach, monitoring adverse events and evaluating overall survival and progression-free disease rates.
- - Researchers aimed for at least a 70% progression-free survival rate at 6 months to justify the need for further Phase II studies on this promising technique.
Background: Ependymal cysts (EC) typically present supra-tentorially near the lateral ventricle, juxta ventricular, or temporoparietal regions. Previous cases have also identified infratentorial EC of the brainstem, cerebellum, and subarachnoid spaces. They are mostly asymptomatic.
View Article and Find Full Text PDFBackground: Rarely, Pituitary adenomas (PA) can co-occur with intrasellar or intracavernous aneurysms. There is currently no clear guidance for the management of this dual pathology. We attempt to provide an algorithm to help guide clinical decision making for treatment of PAs co-occurring with adjacent cerebral aneurysms.
View Article and Find Full Text PDFPurpose: Pre-clinical evidence suggests bevacizumab (BV) depletes the GBM peri-vascular cancer-stem cell niche. This phase I/II study assesses the safety and efficacy of repeated doses of superselective intra-arterial cerebral infusion (SIACI) of BV after blood-brain barrier disruption (BBBD).
Methods: Date of surgery was day 0.