Farm Safety: A Tale of Translational Research and Collaboration.

Children who live or work on farms are at a high risk for injury and death, yet few resources are available to reduce the danger of injury. Research findings establish the need for farm safety in preschool children. However, barriers to interventional research have limited the development of established strategies to help reduce the risk.

A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C.

The hepatitis C virus (HCV) infects more than 180 million people worldwide, with long-term consequences including liver failure and hepatocellular carcinoma. Quercetin bioflavonoids can decrease HCV production in tissue culture, in part through inhibition of heat shock proteins. If quercetin demonstrates safety and antiviral activity in patients, then it could be developed into an inexpensive HCV treatment for third world countries or other affected populations that lack financial means to cover the cost of mainstream antivirals.

Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B.

Acute on chronic liver failure (ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Early Hodgkin's lymphoma (HL) was unmasked with initiation of the anti-viral treatment which may have exacerbated ACLF.

Chronic hepatitis B and hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related deaths. More than 80% of HCC cases are from the Asian and African continents, and more than 50% of cases are from mainland China. Approximately 350 million to 400 million persons are chronically infected with hepatitis B virus (HBV), and this virus is the most common cause of HCC worldwide.

Timing of hepatitis C antiviral therapy in patients with advanced liver disease: a decision analysis model.

Antiviral therapy for the treatment of hepatitis C virus (HCV) infection is used before and after liver transplantation. The objective of this study was to determine the most cost-effective timing for pegylated interferon/ribavirin therapy in patients with advanced liver disease infected with genotype 1 HCV. A Markov model was constructed to compare treatment strategies: (1) no treatment, (2) antiviral therapy in patients with compensated cirrhosis, (3) antiviral therapy in patients with decompensated cirrhosis, and (4) antiviral therapy in patients with progressive fibrosis due to recurrent HCV post-transplantation.

Down on the farm: preventing farm accidents in children.

Agriculture continues to rank as the most dangerous industry in the United States. The objectives of this pilot study were to identify the incidence of care provided to children involved in farm accidents, examine barriers to utilization of farm safety materiaJs by primary health care practitioners (PHCPs), and determine the percentage of PHCPs who provide anticipatory guidance related to farm safety. Pender's revised Health Promotion Model (2006) was used.