Publications by authors named "Amy McCalla-Martin"
Article Synopsis
- A 40-year-old female white rhinoceros developed chronic nail-bed abscesses and, due to worsening symptoms, was switched to a nonsteroidal anti-inflammatory drug, firocoxib.
- Approximately 7 days later, the rhino exhibited skin lesions characterized by vesicles and bullae on its thorax, abdomen, and limbs, with no infectious agents found in cytology and culture tests.
- Histological analysis revealed significant skin damage similar to drug reactions observed in humans, leading to a suspicion of an adverse reaction to firocoxib.
This study was undertaken to characterize the effects of constitutive expression of the hedgehog transcriptional activator, Gli2, in porcine skin. The keratinocyte-specific human transgene, K5-hGli2 Delta N, was used to produce transgenic porcine lines via somatic cell nuclear transfer techniques. In mice, K5-hGli2 Delta N induces epithelial downgrowths resembling basal cell carcinomas.
View Article and Find Full Text PDFThe Arf tumor suppressor (also known as Cdkn2a) acts as an oncogene sensor induced by ;abnormal' mitogenic signals in incipient cancer cells. It also plays a crucial role in embryonic development: newborn mice lacking Arf are blind due to a pathological process resembling severe persistent hyperplastic primary vitreous (PHPV), a human eye disease. The cell-intrinsic mechanism implied in the oncogene sensor model seems unlikely to explain Arf regulation during embryo development.
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