Publications by authors named "Amy Marino"
Association of activin A and postpartum blood pressure in peripartum cardiomyopathy.
Pregnancy Hypertens
December 2023
Article Synopsis
- Activin A, a protein, is linked to chronic hypertension, heart failure, and hypertensive pregnancy disorders but its role in blood pressure during peripartum cardiomyopathy (PPCM) was previously unexplored.
- A study of 82 women with PPCM examined the relationship between blood pressure and serum levels of activin A and another biomarker, finding significant correlations specifically in those with a history of hypertensive disorders.
- The strongest correlation was observed between activin A and diastolic blood pressure in women with preeclampsia, indicating its potential importance in regulating blood pressure for those affected by hypertensive disorders during pregnancy.
Objective: Pregnancy-related infective endocarditis (IE) caries a high risk of morbidity and mortality. With increasing intravenous drug abuse (IVDA) amid the opioid epidemic, the risk factor profile may be shifting. In this case series, we aimed to describe risk factors and outcomes for peripartum IE in a contemporary cohort.
View Article and Find Full Text PDFBackground: Immune dysregulation is implicated in the development and clinical outcomes of peripartum cardiomyopathy (PPCM).
Methods And Results: 98 women with PPCM were enrolled and followed for 1 year postpartum (PP). LVEF was assessed at entry, 6-, and 12-months PP by echocardiography.
Background: Oncotype DX (ODX) is a genomic assay of tumor tissue that is utilized to predict the likelihood of recurrence and benefit of chemotherapy in breast cancer patients. Five to 10% of breast cancers are hereditary, and hereditary syndromes may not be uncovered through family history alone. We hypothesized that high ODX recurrence score (RS) may signal a potential hereditary cancer risk.
View Article and Find Full Text PDFThe etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed.
View Article and Find Full Text PDFWe present a case of ectopia cordis with a complex single-ventricle congenital heart defect in association with pentalogy of Cantrell. Management by a skilled multidisciplinary team was critical for patient survival. Early fetal diagnosis and the use of advanced imaging techniques allowed adequate time for planning and identified critical anatomic details.
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