Manual and continuous bladder irrigation: Best practices.

Bladder irrigation is performed to restore or maintain the patency of an indwelling urinary catheter. This article outlines the best practices to perform this procedure and prevent adverse events.

Transitioning Into Practice: Reflections and Advice for the New Clinical Nurse Specialist.

Purpose/objectives: The purposes of this article are to explore the shared experiences and feelings of clinical nurse specialists (CNSs) who were new to the role and to identify strategies that were helpful in making the transition.

Description Of Project/program: Transitioning to a CNS role may be challenging and emotional, causing fear or anxiety. The authors reflected on their experiences of transitioning into CNS practice.

His and Hers: Economic Factors and Relationship Quality in Germany.

Research has linked economic factors to relationship quality in the United States, primarily using cross-sectional data. In the current study, 2 waves of the Panel Analysis of Intimate Relationships and Family Dynamics data ( = 2,937) were used to test the gendered association between economic factors and relationship satisfaction among young German couples. In contrast to U.

mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis.

Kaposi sarcoma originates from endothelial cells and it is one of the most overt angiogenic tumors. In Sub-Saharan Africa, where HIV and the Kaposi sarcoma-associated herpesvirus (KSHV) are endemic, Kaposi sarcoma is the most common cancer overall, but model systems for disease study are insufficient. Here, we report the development of a novel mouse model of Kaposi sarcoma, where KSHV is retained stably and tumors are elicited rapidly.

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.

KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a.

Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements.

Purpose: A multicenter, open-label, phase II trial was conducted to evaluate the efficacy, safety, and tolerability of selumetinib in iodine-refractory papillary thyroid cancer (IRPTC).

Experimental Design: Patients with advanced IRPTC with or without follicular elements and documented disease progression within the preceding 12 months were eligible to receive selumetinib at a dose of 100 mg twice daily. The primary endpoint was objective response rate using Response Evaluation Criteria in Solid Tumors.

A decade of advances in cytotoxic chemotherapy for metastatic colorectal cancer.

Over the past decade treatment for metastatic colorectal cancer (mCRC) has advanced beyond single-agent fluoropyrimidine use to include various cytotoxic combination regimens and novel targeted therapies. Despite the targeted therapy era, traditional cytotoxic agents remain the mainstay of therapy. Improvements in survival in mCRC can be attributed mostly to combination therapy, with enhanced efficacy due to optimization of fluoropyrimidine dosing and the addition of irinotecan and/or oxaliplatin.

Economic Factors and Relationship Quality Among Young Couples: Comparing Cohabitation and Marriage.

Are economic resources related to relationship quality among young couples, and to what extent does this vary by relationship type? To answer these questions, we estimated regression models predicting respondent reports of conflict and affection in cohabiting and married partner relationships using the National Longitudinal Study of Youth, 1997 (NLSY97, N = 2,841) and the National Longitudinal Study of Adolescent Health (Add Health, N = 1,702). We found that economic factors are an important predictor of conflict for both married and cohabiting couples. Affection was particularly responsive to human capital rather than short-term economic indicators.

Assessing geriatrics in undergraduate medical education: two different approaches.

Most medical schools do not have a separate course in geriatrics, but rather incorporate geriatrics into existing courses. Tracking and assessing curriculum content is more difficult in this setting. This paper describes and compares two approaches to assess curriculum content in geriatrics: a survey of course directors and a course objectives review.

Use of a questionnaire to screen for frailty in the elderly: an exploratory study.

Background And Aims: In a pilot study of community-dwelling geriatric clinic patients (N=48, aged 63-90) we examined the use of a questionnaire to classify frailty status by comparing it with standardized markers of frailty. The questionnaire, developed by Strawbridge et al. in 1998, defines frailty as difficulty in more than one of four domains of functioning: physical, cognitive, sensory, and nutritive.

Trends of abdominal adiposity in white, black, and Mexican-American adults, 1988 to 2000.

Objective: To describe changes in the distribution of waist circumference (WC) and abdominal obesity (AO) in white, black, and Mexican-American adults from 1988 through 2000.

Research Methods And Procedures: Nationally representative cross-sectional surveys of adults 20 to 79 years of age were examined using data from U.S.