Publications by authors named "Amy Lan Neusaenger"
Article Synopsis
- Recent studies reveal that an amorphous drug-polymer salt can remain stable under hot and humid conditions while offering quick drug release, especially influenced by how well salt is formed.
- The researchers looked at the salt formation between lumefantrine (a drug) and various acidic polymers, using a method called "slurry synthesis," which proved to be more effective than traditional techniques.
- The findings indicate that the ability of polymers to protonate lumefantrine depends more on the density of acidic groups present than on their structural design, guiding choices for optimal polymers in drug formulations.
An amorphous drug-polymer salt (ADPS) can be remarkably stable against crystallization at high temperature and humidity (e.g., 40°C/75% RH) and provide fast release.
View Article and Find Full Text PDFAmorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug-polymer salts to meet these goals.
View Article and Find Full Text PDF