Neurologic abnormalities and cerebrospinal fluid changes in horses administered fumonisin B1 intravenously.

The objective of this experiment was to characterize a dose-dependent toxic effect of fumonisin B1 (FB1) and to document initial neurologic signs, clinical progression, and terminal cerebrospinal fluid (CSF) changes in horses administered FB1 IV. Seventeen healthy horses were administered 0.00 (n = 4), 0.

Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses.

Objective: To determine whether cardiovascular dysfunction is evident in horses with leukoencephalomalacia experimentally induced by administration of fumonisin B1.

Animals: 11 healthy horses of various breeds (body weight, 252 to 367 kg).

Procedure: Horses were randomly assigned to 3 groups and administered fumonisin B1 daily.