Publications by authors named "Amy L Thompson"

Purpose: Correction of refractive error in children is important for visual and educational development. The aim of this questionnaire-based study was to explore paediatric refractive correction by optometrists in England.

Methods: An online questionnaire was piloted and distributed to optometrists in England.

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Objective: Many clinical laboratory scientists find themselves in a management position during their career, but have limited training to assume this role. The Clinical Laboratory Tycoon case study was designed to submerge students into the laboratory business by having the participant act as a laboratory manager with the capacity to make all the decisions about his or her own lab.

Design: The student participant completed a set of modules that each related to varying aspects of managing a laboratory including selecting what tests to offer, hiring employees, marketing the services, setting goals, budgeting, and evaluating overall success.

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Article Synopsis
  • The study investigates how basic helix-loop-helix (bHLH) transcription factors influence the expression of Na(V) 1.4 Na(+) channels in skeletal muscle using C2C12 muscle cells as a model.
  • It explores how bHLH factors mitigate repression from a specific E box by attracting positive transcription factors, revealing that known and novel factors (ZEB and REB) interact with the repressor E box.
  • The research highlights the role of nuclear factor I (NFI) in this process, showing that mutations affecting its binding sites reduce the effectiveness of myogenin and MRF4 in counteracting transcriptional repression.
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The factors that regulate transcription and spatial expression of the adult skeletal muscle Na+ channel, Na(V) 1.4, are poorly understood. Here we tested the role of the transcription factor MRF4, one of four basic helix-loop-helix (bHLH) factors expressed in skeletal muscle, in regulation of the Na(V) 1.

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