Synopsis of recent research by authors named "Amy L Paguirigan"
- Amy L. Paguirigan's research primarily focuses on the development and optimization of microfluidic devices and techniques for single-cell analysis, including sorting and dispensing, to enhance the understanding of cellular heterogeneity and its implications in disease processes, such as cancer.
- Key innovations include a self-digitization dielectrophoretic (SD-DEP) chip for high-efficiency single-cell capture and analysis, as well as various droplet manipulation systems that employ electrohydrodynamic actuation for accurate single-cell and single-droplet dispensing.
- The findings emphasize the importance of precise single-cell techniques for assessing genetic variability, tracking clonal evolution in cancers, and generating insights into intercellular differences, ultimately guiding therapeutic decisions and improving disease outcomes.
