Fluconazole prophylaxis in extremely low birth weight infants and neurodevelopmental outcomes and quality of life at 8 to 10 years of age.

Objective: To examine the long-term effects of fluconazole prophylaxis in extremely low birth weight infants.

Study Design: Neurodevelopmental status and quality of life of survivors from a randomized, placebo-controlled trial of fluconazole prophylaxis were evaluated at 8 to 10 years of life using the Vineland Adaptive Behavior Scales-II (VABS-II) and the Child Health Questionnaire Parent-Completed Form 28 (CHQ-PF28), respectively.

Results: VABS-II Domain Scores for the fluconazole-treated (n = 21; 9.