Publications by authors named "Amy K Holland"
Bioorg Med Chem
February 2003
Article Synopsis
- Researchers synthesized novel difluorovinyl steroids as potential inhibitors of the enzyme C17(20) lyase, which is essential for testosterone production.
- The method involved using a reagent to react with 17-acetyl steroids to create these compounds.
- An interesting byproduct, abnormal Wittig products, emerged during the synthesis, and the resulting difluoroolefin was identified as a moderately potent, time-dependent inhibitor of the target enzyme.
