Publications by authors named "Amy K Carroll"
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of sotagliflozin, a medication for type 2 diabetes (T2D), in patients with severe chronic kidney disease (CKD4) over 52 weeks.
- Results showed that after 26 weeks, sotagliflozin did not significantly reduce glycated hemoglobin (HbA1c) compared to a placebo, though some improvements in weight and blood pressure were noted.
- The safety profile of sotagliflozin was largely consistent with previous studies, with a notable percentage of patients experiencing adverse events, but serious cardiovascular issues were less common in those receiving the drug.
The cytoprotective activity of MITO-4565, a novel, non-hormonal, estradiol derivative, was evaluated in the S334ter transgenic model of retinitis pigmentosa (RP). Progressive blindness in RP is due to apoptotic death of the photoreceptors, a process mimicked by the animal models [Portera-Cailliau C, Sung C-H, Nathans J, Adler R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.
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