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Publications by authors named "Amy Jia Wang"

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microRNAs regulate human embryonic stem cell division.
Junlin Qi Jenn-Yah Yu Halyna R Shcherbata Julie Mathieu Amy Jia Wang Linlin Wang

Cell Cycle

November 2009

microRNAs (miRNAs) regulate numerous physiological processes such as cell division and differentiation in many tissue types including stem cells. To probe the role that miRNAs play in regulating processes relevant to embryonic stem cell biology, we used RNA interference to silence DICER and DROSHA, the two main miRNA processing enzymes. Consistent with a role for miRNAs in maintaining normal stem cell division and renewal, we found that perturbation of miRNA pathway function in human embryonic stem cells (hESCs) attenuates cell proliferation.

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Synopsis of recent research by authors named "Amy Jia Wang"

  • - Amy Jia Wang's research primarily focuses on the role of microRNAs (miRNAs) in regulating physiological processes such as cell division and differentiation, specifically in human embryonic stem cells (hESCs).
  • - In her 2009 study published in the journal Cell Cycle, Wang demonstrated that silencing key miRNA processing enzymes (DICER and DROSHA) led to impaired cell proliferation in hESCs, highlighting the importance of the miRNA pathway in stem cell biology.
  • - The findings suggest that proper miRNA function is crucial for maintaining normal stem cell division and renewal, indicating that disruptions in this pathway can significantly affect stem cell proliferation.

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