AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca Channels.

To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca nanodomain is a spatially confined signal that arises near open Ca channels. Ca nanodomains near store-operated Orai1 channels stimulate the protein phosphatase calcineurin, which activates the transcription factor NFAT1, and both enzyme and target are initially attached to the plasma membrane through the scaffolding protein AKAP79.