Gynecologic cancer care in the first year of the COVID-19 pandemic.

Objective: To analyze the impact of the early COVID-19 pandemic on the diagnosis and initiation of treatment for patients with gynecologic cancer.

Methods: Patients diagnosed with gynecologic cancer in the National Cancer Database during 2017-2020 were included. For the first aim, incidence rate ratios were calculated to compare gynecologic cancer diagnosis in the first year of the COVID-19 pandemic to the three years prior, and factors associated with a reduction in diagnosis were identified.

Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death.

High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted therapy, given that these tumors are driven by a high degree of genomic instability (GI) and homologous recombination (HR) defects. Nonetheless, approximately 30% of patients initially respond to treatment, ultimately relapsing with resistant disease.

Enhanced gastric decompression for palliation of malignant bowel obstruction.

Background: Malignant bowel obstruction (MBO) is a sequela of advanced intraabdominal cancer and has a profound impact on quality of life. Common therapy is endoscopic decompressive gastrostomy tube placement. Standard gastrostomy tubes are poorly designed to completely evacuate the dependent portions of the stomach due to their location on the anterior gastric wall.

Current Life Experiences in Veterans with Limb Loss: A Description of Survey Methods and Summary Results.

Purpose: To present the methods and summary findings of a nationwide survey on the current life experiences of Operation Iraqi Freedom/Operation Enduring Freedom (OEF/OIF) Veterans with limb loss.

Methods: A questionnaire was sent to Veterans with items covering sample demographics, summaries of health status, prosthesis usage and fit, employment experience, and use and satisfactions with support services and providers.

Results: 158 Veterans completed the survey.

Veterans of Operation Enduring Freedom and Operation Iraqi Freedom: Employment Status Following Traumatic Amputation.

Purpose: The population of veterans experiencing traumatic amputation grows at a rate disproportionate to the general population. This study explores the current employment experience of veterans living with traumatic amputation and the relationship among demographic, health and amputation related characteristics, employment status and service utilization, and perceived barriers to employment.

Methods: Survey data from veterans of Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) were gathered on health and amputation, employment, service utilization, and perceived barriers to employment.

Assessing the fear of COVID-19 scale among health care workers in Israel: a psychometric validation study.

We explored the psychometric properties of the Hebrew version of the Fear of COVID-19 (FCV-19S) scale among health care workers in a large medical center in Israel. Participants ( = 705) completed the FCV-19S scale, as well as resilience, subjective well-being, and meaning in life using validated scales. Results showed a two-factor structural model accounting for 79.

A changing world, again. How Appreciative Inquiry can guide our growth.

COVID-19 is an interconnecting, cascading tsunami of up-rootedness and change on many levels. The global challenge we face is twofold: 1) how do we sustain our psychological, physical, social and economic capital and wellbeing in a time of great uncertainty; and 2) how do we adapt and create a new existence in an altered reality? Appreciative Inquiry (AI) is a well-documented approach to helping individuals and systems move from a deficit-based paradigm to a strengths-based perspective. AI holds myriad potential benefits for individuals, communities, and macro systems to build resilience and promote growth during and after COVID-19.

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.

Somatic mutation of the protein phosphatase 2A (PP2A) Aα-subunit gene is highly prevalent in high-grade endometrial carcinoma. The structural, molecular, and biological basis by which the most recurrent endometrial carcinoma-specific mutation site P179 facilitates features of endometrial carcinoma malignancy has yet to be fully determined. Here, we used a series of structural, biochemical, and biological approaches to investigate the impact of the P179R missense mutation on PP2A function.

Factors Influencing Functional Outcomes and Return-to-Work After Amputation: A Review of the Literature.

Purpose Amputation is a life changing event that can significantly impact an individual's physical and mental well-being. Our objective was to review literature exploring the impact of amputation upon a person's functioning and inclusion in the workplace. Methods Medline, CINAHL, and PsycINFO were searched using keywords related to amputation, employment and community reintegration.

Operation Enduring Freedom and Operation Iraqi Freedom Veterans with amputation: An exploration of resilience, employment and individual characteristics.

Background: Since 2002 approximately 1,700 US military service members have experienced trauma related amputations from injuries incurred in Afhanistan and Iraq (Fisher, 2015).

Objective: This study explores the variables of resilience, individual characteristics, and employment status of a sample of these Veterans who served in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) and sustained an amputation.

Methods: Veterans identified through the VA Corporate Data Warehouse (N = 165) completed a survey on their experiences following amputation.

Standardization of Laparoscopic Operative Reporting: Improving Gynaecological Surgeon Communication.

Objective: No standardization of quality of operative reporting currently exists, and this represents a missed opportunity for communication among health care providers. This study proposed a method to improve operative notes by structuring the findings by six anatomical zones of the pelvis. Objective I was to validate the method of documenting six zones of the pelvis by using intraoperative photography.

Diagnosis and management of endometrial hyperplasia.

Endometrial hyperplasia (EH), with or without atypia, is a common gynecologic diagnosis and a known precursor of endometrial carcinoma, the most common gynecologic malignancy. During the reproductive years, the risk of EH is increased by conditions associated with intermittent or absent ovulation, in particular, polycystic ovary syndrome. After menopause when ovulation has ceased, EH is more common in women with conditions that increase levels of circulating estrogen such as obesity or estrogen replacement therapy.

Workplace discrimination and cumulative trauma disorders: the national EEOC ADA research project.

Employment discrimination of persons with cumulative trauma disorders (CTDs) was explored using the Integrated Mission System dataset of the US Equal Employment Opportunity Commission. Demographic characteristics and merit resolutions of the Charging Parties (persons with CTD) were compared to individuals experiencing other physical, sensory and neurological impairments. Factors compared also included industry designation, geographic region, and size of Respondents against which allegations were filed.