Publications by authors named "Amy Guimaraes-Young"
Article Synopsis
- The study utilizes findings from The Cancer Genome Atlas and a specific algorithm to classify endometrial carcinoma into four distinct subgroups based on molecular and immunohistochemical characteristics.
- Over the first 13 months, 188 tumors were analyzed through a combination of IHC and a next-generation sequencing (NGS) assay focused on 56 genes, leading to classification into the following subgroups: POLE-mutated (5.3%), mismatch repair deficient (27.7%), no specific molecular profile (45.7%), and p53 abnormal (21.3%).
- The NGS analysis uncovered further distinctions among these subgroups, such as differences in pathway activation and mutation frequencies, resulting in a comprehensive testing protocol aimed
The phosphatidylinositol 3-kinase (PI3K) pathway is an intracellular pathway activated in response to progrowth signaling, such as human epidermal growth factor receptor 2 (HER2) and other kinases. Abnormal activation of PI3K has long been recognized as one of the main oncogenic drivers in breast cancer, including HER2-positive (HER2+) subtype. Somatic activating mutations in the gene encoding PI3K alpha catalytic subunit () are present in approximately 30% of early-stage HER2+ tumors and drive therapeutic resistance to multiple HER2-targeted agents.
View Article and Find Full Text PDFThe Sleeping Beauty (SB) transposon insertional mutagenesis system offers a streamlined approach to identify genetic drivers of cancer. With a relatively random insertion profile, SB is uniquely positioned for conducting unbiased forward genetic screens. Indeed, SB mouse models of cancer have revealed insights into the genetics of tumorigenesis.
View Article and Find Full Text PDFThe importance of canonical Wnt signaling to murine uterine development is well established. Mouse models in which uterine-specific Wnt ligands, β-catenin, or Lef1 are disrupted result in failure of postnatal endometrial gland development. Sox17 is a transcription factor characterized in numerous tissues as an antagonist of Wnt signaling.
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