Post-Transcriptional Genetic Silencing of to Treat Sickle Cell Disease.

Background: Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations by mitigating sickle hemoglobin polymerization and erythrocyte sickling. is a repressor of γ-globin expression and HbF production in adult erythrocytes.

A Parenting and Life Skills Intervention for Teen Mothers: A Randomized Controlled Trial.

Unlabelled: : media-1vid110.1542/5985300176001PEDS-VA_2018-2303 BACKGROUND: Teen mothers often present with depression, social complexity, and inadequate parenting skills. Many have rapid repeat pregnancy, which increases risk for poor outcomes.

Predictors of soft-tissue complications and deep infection in allograft reconstruction of the proximal tibia.

Background And Objectives: Reconstruction of the proximal tibia after wide resection of malignant tumors in the pediatric population is very challenging. Advocates of allograft reconstruction argue as advantages bone preservation, biological reconstruction that facilitates reattachment of the extensor mechanism and other soft-tissue structures, delay of metallic prosthesis use and preservation of the distal femoral growth plate. However, complications are significant, infection being very common.