Imaging diagnosis--Arterial and venous thromboses of the proximal limb in two thoroughbred racehorses.

Thromboses of the cranial tibial vein (Horse 1) and brachial, median, and cranial circumflex humeral arteries (Horse 2) were identified as causes of unilateral lameness in two Thoroughbred racehorses. Nuclear scintigraphy was performed for suspicion of long bone stress fractures but instead allowed identification of unusual areas of increased radiopharmaceutical uptake within soft tissues of the affected limbs. Ultrasonography of these regions allowed identification of occlusive thrombi within a 25 cm length of the cranial tibial vein (Horse 1) and variable lengths of affected arteries in Horse 2.

Effects of intravenous administration of pirfenidone on horses with experimentally induced endotoxemia.

Objective: To characterize effects of IV administration of pirfenidone on clinical, biochemical, and hematologic variables and circulating tumor necrosis factor (TNF)-alpha concentrations in horses after infusion of a low dose of endotoxin.

Animals: 18 healthy adult horses.

Procedures: Horses were randomly assigned to 3 groups (n = 6 horses/group) and administered an IV infusion of 30 ng of endotoxin/kg or saline (0.

Pharmacokinetics and clinical effects of pirfenidone administered intravenously in horses.

Objective: To characterize the plasma pharmacokinetics and clinical effects of pirfenidone administered IV in healthy horses.

Animals: 6 adult horses.

Procedures: A 15 mg/kg dose of pirfenidone was administered IV over 5 minutes.