Synopsis of recent research by authors named "Amy E Moran"
- Amy E Moran's recent research primarily explores the interplay between androgen receptor (AR) activity and immune responses in various cancers, revealing that increased AR activity corresponds with decreased immune cell infiltration and poorer outcomes to immunotherapy across multiple cancer lineages.
- She investigates the role of immune checkpoint proteins, particularly PD-1, in regulating T cell dynamics during development and their implications for immunotherapy responses, particularly in the context of thymic activity.
- Moran's work also delves into the effects of androgen deprivation therapy on thymic regeneration and its potential to bolster antitumor immunity, as well as the influence of gastrointestinal microbiota on treatment response in metastatic prostate cancer.
