Publications by authors named "Amy C Adams"
Article Synopsis
- After prolonged seizure activity, hyperexcitability in the medial entorhinal cortex-hippocampal circuit may play a role in developing temporal lobe epilepsy in animal models.
- The study used mEC-HC brain slices from rats treated with low-dose kainic acid and observed increased spontaneous burst activity in the mEC compared to control rats, indicating increased excitability.
- Anticonvulsants like retigabine effectively reduced spontaneous burst frequency in both treated and control slices, suggesting this model could help identify new treatments for drug-resistant epilepsy.
