[Effect of external gamma-irradiation on the genetic apparatus of somatic cells of rat fetus].

Cytogenetic effects of different radiation dose rate and dose value were studied in fibroblasts of 20-day old rat fetuses and new-born ratlings. Quantitative and qualitative changes in the occurrence frequency in the spectrum of chromosome aberration types were revealed and changes in aneuploid fibroblast ratio were observed. The damages in the fibroblast chromosome structure of fetuses remain after birth (2-day-old ratling) and they were also observed in fetuses of the second generation.

[Development of rat embryos after prolonged irradiation of ovocytes at the stage of immature follicles].

It was shown that the prolonged low-dose irradiation (up to 0.6 Gy) of the immature ovocytes of young rats (21-28 days old) caused delay of development of preimplantation embryos after fertilization of ovicells.

[The status of ovary capillaries in fetuses of White rats after irradiation in various periods of its embryogenesis ].

The peculiarities of reactions of blood capillaries and their cell structures in the ovary of 20-days old foetus to the irradiation in embryogenesis were revealed; it was shown for the first time that the character and direction of changes in principal morphofunctional parameters depended on the dosage, power of gamma-irradiation and the age of the developing organism by the exposure moment.

[The dynamics of folliculogenesis in the ovary of the progeny of animals irradiated in embryogenesis and early postnatal life].

The prolonged irradiation with 1.0 Gy dose in prenatal and early postnatal periods of development of rats leads to the disturbance in the rate of follicular growth, the reduction of their pool, mainly the pool of young forms of oocytes. Processes of degeneration and destruction occur and develop in the ovary of both the irradiated rats and their first progeny.

[Changes in the adrenergic innervation of the large intestine in the postnatal ontogeny of the white rat].

Age-related changes of adrenergic structures in intramural (myenteric and submucosal) plexuses of the albino rats large intestine were studied in different stages of postnatal ontogenesis (5 days, 1,5,13 and 24-26 months). It was established that adrenergic link of innervation develops most rapidly during the first month of postnatal life. This results in decrease of adrenergic nerve fibres number and catecholamine content in them with the simultaneous hypertrophy of part of the structures.

[The reaction of blood lymphocyte dehydrogenases after the incorporation of 131I and 137Cs radionuclides].

The data on the activities of dehydrogenases in rat blood lymphocytes 30, 90, 180 and 365 days after separate and combined effect of 131I (dose of 2.5 MBq/kg) and 137Cs (dose of 1.6 Mbq/kg) are presented.

[Effect of single-dose external gamma-irradiation of 0.5 g on the development of rat's embryos].

Primigravida 4-month rats were exposed to single whole-body external gamma-radiation (137Cs, 0.5 Gy) during organogenesis on days 9 and 15 of pregnancy. The embryotoxic effect of radiation was studied on the 20th day of pregnancy.

[Redox enzymes in the tissues of the large intestine in the postnatal ontogeny of rats].

Using histochemical methods, age-related changes in activity of some redox enzymes in muscular and superficial layers of the mucous membrane, as well as in neurons of the myenteric nervous plexus of the large intestine have been studied in albino rats 5-day-old, 1-, 5-, 13-, 24-month-old. In young animals (1-5-month-old) an essential increase of the enzymatic activity of the energy metabolism takes place, in mature animals--stabilization of these processes, senescence brings about multidirectional changes in them. Manifestation degree of the changes in energy metabolism, occurring in old age are determined by certain metabolic and functional peculiarities in the organ tissue.

[An analysis of the cytochemical oxidoreductase activity of the peripheral blood lymphocytes of rats exposed to 131I].

Savage of rats with I131 at 2.5 MB/kg level followed with changing in red-ox processes in lymphocytes. It is caused not only by irradiation, but also by the indirect influencing of the thyroid gland's hormones.

[Changes in the cell pool of the intramural neural plexus of the large intestine during postnatal development].

Using a complex of morphological, morphometrical and histochemical methods, morphofunctional regularities for the age-related changes in the cell pool of intramural (myenteric and submucosal) nervous plexuses have been studied in the large intestine of albino rats during postnatal development. Three periods in development and differentiation of neurocellular resources of the intestine have been distinguished: progressive growth, relative stabilization and regressive phenomena. Peculiarities in structural-chemical transformation of cellular elements have been revealed during each period.

[The dynamics of the histochemical activity of the oxidoreductases in the myocardium of mature and old rats undergoing whole-body gamma irradiation at a dose of 1 Gy].

The effect of gamma radiation (1 Gy) on redox enzyme activity in heart cells of adult and old rats was studied during a month following the exposure. It was shown that the activity of diaphorases and succinate dehydrogenase decreased whereas that of other tricarboxylic acid cycle enzymes and lactate dehydrogenase underwent phase changes.

[Changes in the adrenergic structures of the human stellate ganglia in pathological states].

Stellate ganglia from patients who had succumbed to various diseases were examined by a fluorescent histochemical technique using 2% glyoxylic acid. Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death. All adrenergic structures of the ganglia were clearly demonstrable after early autopsies of those who had died suddenly from pulmonary artery thromboembolism in the absence of other abnormalities.

[Histofluorescent study of catecholaminergic cells of the mammalian autonomic nervous system].

The structure, distribution and fluorescent properties of catecholaminergic cells in the peritoneal sympathetic ganglia and in the intramural plexus of the digestive tract, in the heart and aorta have been studied in white rats (Wistar strain), in dogs, cats and in man. It has been stated that the sympathetic ganglia and the intramural plexus have different monoaminergic cells: large adrenergic (sympathetic) neurons and small intensely fluorescent (SIF) cells. In young and mature cells, mainly catecholamines are accumulated in their cytoplasm.

[Luminescent-histochemical study of the sympathetic innervation of the large intestine in some mammals].

It has been established that specifically fluorescening fibres and their endings as well as neurons along the length of the large intestine and in the thick of its wall have uneven distribution in cats, albino rats and dogs. A considerable part of fibres are concentrated in the muscular-intestinal, submucose plexuses and in the circular muscular layer. The greatest amount of fibres can be found in the rectum wall.