Defining the relationship between clinician-rated ECOG performance status and patient-reported health-related quality of life scores in men with metastatic hormone-naïve prostate cancer.

Background: Performance status and health-related quality of life (HRQoL) are important parameters in the management of metastatic prostate cancer. The clinician-rated Eastern Cooperative Oncology Group performance status (ECOG-PS) may not relate with the patient-reported HRQoL because the later puts into consideration some aspects of health that are not captured by the former. The aim of this study is to define the relationship between clinician-rated ECOG-PS and the patient-reported HRQoL in men with metastatic hormone-naïve prostate cancer (mPCa).

Wound bed preparation using nonsurgical methods: A prospective comparative study of honey versus unripe papaya ().

Background: The rapidity of wound bed preparation is determined in part by the type of dressing agent employed. The extension phase in which the wound is characterized by the presence of sloughs and eschar and microbial invasion could be managed nonsurgically.

Objective: The objective of this study was to compare the rapidity of wound bed preparation using unripe papaya versus honey.

Prevalence and Distribution of Postvoid Residual Urine Volume in a Hospital-Based Sample of Men with Symptomatic Benign Prostatic Hyperplasia.

Background: Benign prostatic hyperplasia (BPH) is a known cause of bladder outlet obstruction (BOO) in aging men. Patients present with lower urinary tract symptoms (LUTS), elevated postvoid residual urine (PVR), and reduced peak flow rate of urine. Although urodynamic study is the gold standard for diagnosing and quantifying BOO, it is invasive and as such urologists in their routine practice frequently rely on less invasive methods like PVR estimation to objectively assess BOO.

Correlation between Physician-Administered International Prostate Symptoms Score and Peak Urine Flow Rate in Assessment of Benign Prostatic Enlargement Patients.

Background: To determine the correlation between international prostate symptom score (IPSS) questionnaire, completed by benign prostatic enlargement patients with the aid of their physicians and the peak urine flow rate from uroflowmetry.

Materials And Methods: This was a prospective study carried out over a period of one year (which year and which period). IPSS questionnaire was administered, and uroflowmetry done for 76 consecutive patients from urology clinic of University of Nigeria Teaching Hospital (UNTH) who consented to the study.

Outcome of transurethral resection of the prostate (TURP) using 5% dextrose water as irrigant.

Background: TURP remains the gold standard for simple prostatectomy presently. Different fluids have been used for irrigation while performing monopolar TURP. The choice of irrigation fluid depends on a lot of factors.

Unusual case of bladder stone with an embedded scalpel blade.

ME is an 84-year old man who presented with a 3-year history of storage urinary symptoms associated with strangury. He had an open radical prostatectomy and direct visual internal urethrotomy 10 years prior to presentation for early prostate cancer and partial urethral stricture, respectively. A plain abdominal X-ray revealed a bladder stone in which there was an opaque foreign body embedded within the stone.

Malament stitch and increased risk of bladder neck stenosis: any association following open prostatectomy in Enugu Southeast Nigeria.

Background: Malament stitch is one of the effective techniques employed to minimize bleeding in simple open prostatectomy but concerns about possibility of increased risk of bladder neck stenosis has limited its routine use.

Aim: We studied patients who had open prostatectomy with Malament stitch to determine the incidence of bladder neck stenosis amongst them.

Material And Methods: This was a prospective study of 72patients who had simple open prostatectomy in which malament stitch was applied from 2010 to 2020.

Challenges and Innovations Brought about by the COVID-19 Pandemic Regarding Medical and Pharmacy Education Especially in Africa and Implications for the Future.

Background: Multiple measures introduced early to restrict COVID-19 have dramatically impacted the teaching of medical and pharmacy students, exacerbated by the lack of infrastructure and experience with e-learning at the start of the pandemic. In addition, the costs and reliability of the Internet across Africa pose challenges alongside undertaking clinical teaching and practical programmes. Consequently, there is a need to understand the many challenges and how these were addressed, given increasingly complex patients, to provide future direction.

Pregnancy and gastric cancer: diagnostic and treatment dilemma.

Gastric cancer in pregnancy is an extremely rare entity. The incidence of gastric cancer is more in elderly patients and higher in the male population. Gastric cancer symptoms can be nausea, vomiting and epigastric discomfort which is similar to early pregnancy symptoms.

Transperineal versus transrectal prostate biopsy: our findings in a tertiary health institution.

Context And Objective: Prostate cancer is a major public health issue. Its incidence is rising, especially in Nigeria. Prompt diagnosis is necessary by histology.

The value of international prostate symptom scoring system in the management of BPH in Jos, Nigeria.

Objective: To determine the value of international prostate symptom scoring (IPSS) system in management of patients with benign prostatic hyperplasia (BPH) in Jos, Nigeria.

Materials And Methods: This was a prospective study of 104 newly diagnosed patients with BPH from June 2006 to July 2007. Patients' symptoms were initially evaluated by administering a pretreatment IPSS/Quality of Life Score (QOLS).

Acute perforated peptic ulcer: on clinical experience in an urban tertiary hospital in south east Nigeria.

Background: Acute perforated peptic ulcer is a leading cause of generalized peritonitis and its management has continued to be a challenging task in our environment.

Objective: There is a paucity of published reports on acute perforated peptic ulcers in our environment. This study was conducted to evaluate the different pattern of risk factors clinical presentations, management and clinical outcome of patients with acute perforated peptic ulcer in our setting and to highlight the factors that continue to account for the high mortality and morbidity as seen here.

Ileal perforation due to typhoid fever - review of operative management and outcome in an urban centre in Nigeria.

Background: The management of ileal typhoid perforation is a challenging task in our environment. Lack of incidence data base and poor financial resources preclude adequate prevention of this public health menace.

Objectives: For now the focus will remain the effective and strategic management of this complication to reduce the morbidity and mortality.

A case of vulval swelling secondary to female circumcision posing a diagnostic dilemma.

Introduction: The practice of FGM is most prevalent in the African countries such as Nigeria, Ethiopia, Sudan, Egypt, and some area of the Middle East. It is not restricted to any ethnic, religious or socioeconomic class. There are many reasons for perpetuation of this practice; the most common are cultural and religious beliefs.

Iatrogenic ureteric injuries complicating open obstetric and gynaecologic operations in South East Nigeria - case series.

Background: Iatrogenic ureteric injury(IUI) in open obstetric and gynaecological surgeries is uncommon, with an incidence of 0.4-2.5%.

Abdominal pregnancy- a case report.

A case of abdominal pregnancy in a 39 year old female gravida 4, para 0(+3) is presented. Ultrasonography revealed a viable abdominal pregnancy at 15 weeks gestational age. She was initially managed conservatively.

NHS abortion services: referral pathways and outcomes.

The aim of this study was to assess the effectiveness of the different referral pathways to accessing abortion services. It was a retrospective observational study comparing abortion referral processes in two district hospitals. The results showed that 149 patients self-accessed the NHS abortion service in group A compared with group B of 365 formally referred patients.

Repeat abortion: facts and issues.

Background: The commonest reason for undertaking termination of pregnancy (TOP) in the UK is as defined by Clause 2 of the Abortion Act. There are no agreed criteria for defining 'recurrent abortion seekers'. We aimed to review the characteristics of women requesting termination of at least two consecutive pregnancies within 24 months of the first and to identify any factors for seeking repeat TOP.

The impact of a dedicated antenatal clinic on the obstetric and neonatal outcomes in adolescent pregnant women.

This retrospective observational study was designed to study the impact of a dedicated antenatal clinic service on obstetric and neonatal outcomes among teenage mothers in the maternity unit of a district general hospital in the UK. Outcomes were measured to investigate improvement in obstetric and neonatal outcomes before, and 12 months after the establishment of dedicated clinic for teenage pregnant women. Significant improvement in the birth weight was observed p = 0.

Teenage pregnancy in the United Kingdom: are we doing enough?

The teenage pregnancy unit's strategy for dealing with the increasing problem of unwanted pregnancy is rather prescriptive and simplistic for such a complex problem. It is not surprising that despite its recent recommendations, the problem has worsened. It is ludicrous to promote efficient ways to provide oral contraceptive pills to teenagers when good evidence of its inconsistent use among this age group is common knowledge.

The oestrogen 'sparing' effect of implanon: a case report and review.

This article presents a case study of the 'oestrogen sparing effect' of etonorgestrel especially high lighting its use in a patient with hypoestrogenism following long-term use of depomedroxyprogesterone acetate (DMPA); still wishing a long-term reversible method of contraception. There are studies demonstrating the effects of both DMPA and etonogestrel on estrogen status, but evidence is sparse, exploring the possibilities of usage of etonorgestrel following demonstration of hypo-oestrogenism with DMPA usage.

Factors affecting outcome of colposuspension.

A prospective follow-up study of 196 women who underwent a colposuspension operation for genuine stress incontinence (GSI) at the Leicester General Hospital between June 1991 and May 1996 (inclusive) was carried out to review the outcome of surgery. The outcome was based on clinical symptomatology, demonstration of stress incontinence in the clinic and limited postoperative urodynamic studies. The clinical cure rate was 91.

Assessment of stillbirth risk and associated risk factors in a tertiary hospital.

We aimed to calculate the stillbirth rate at each gestation and also determine antenatal factors, which may be associated with unexplained stillbirth in a large UK teaching hospital. This was a retrospective study of all the stillbirths between January 1995 and October 1998. There were 27 170 births at > or =24 weeks, gestation during the study period.