Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial.

Background: Tenecteplase is a newer thrombolytic agent with some pharmacological advantages over alteplase. Previous phase 2 trials of tenecteplase in acute ischaemic stroke have shown promising results. We aimed to investigate the safety and efficacy of tenecteplase versus alteplase in patients with acute stroke who were eligible for intravenous thrombolysis.

Morphological and functional development of the interbranchial lymphoid tissue (ILT) in Atlantic salmon (Salmo salar L).

The interbranchial lymphoid tissue (ILT) of Atlantic salmon originates from an embryological location that in higher vertebrates gives rise to both primary and secondary lymphoid tissues. Still much is unknown about the morphological and functional development of the ILT. In the present work a standardized method of organ volume determination was established to study its development in relation to its containing gill and the thymus.

Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke.

Many stroke survivors suffer from poststroke fatigue (PSF) and poststroke depression (PSD), indicating the importance of increasing the base of knowledge about the mechanisms underlying these sequelae. The primary aim of this study was to determine whether activation of the kynurenine (KYN) pathway predicts subsequent fatigue or depression in acute ischemic stroke (AIS) patients. Acute serum levels of 5-hydroxytryptamine (5-HT), tryptophan (TRP) catabolites (TRYCATs), and competing amino acids, as well as subsequent fatigue and depression, were measured in 45 stroke patients.

Inflammation-induced catabolism of tryptophan and tyrosine in acute ischemic stroke.

Whether the inflammatory response that accompanies acute ischemic stroke induces the kynurenine pathway is currently a matter of conjecture. Activation of this pathway may disturb active metabolites. The aim of this study was thus to characterize the catabolism of tryptophan and tyrosine in acute ischemic stroke (AIS) patients, and its association with cytokines, C-reactive protein, and glucose.

Serum levels of cytokines, glucose, and hemoglobin as possible predictors of poststroke depression, and association with poststroke fatigue.

Depression is a frequent and potentially disabling sequela of stroke. In the present study, we investigated the ability of stroke type, infarct volume, and laterality, and the levels of various cytokines and other blood components in the acute phase of acute ischemic stroke (AIS) in 45 patients, to predict the level of depression (Beck Depression Inventory [BDI] score) at 6, 12, and 18 months after its onset. The BDI score at 12 months poststroke was positively correlated with the acute serum level of glucose (r = 0.

Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume.

There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, type, and infarct volume. Forty-five patients with AIS were evaluated.

Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients.

Fatigue is a common but often overlooked symptom after stroke. This study investigated whether stroke type, infarct volume, and laterality, as well as the levels of various cytokines and other blood components in the acute phase of acute ischemic stroke (AIS), can predict the level of fatigue at 6, 12, and 18 months after its onset. In 45 patients with acute stroke, serum levels of C-reactive protein, hemoglobin, glucose, and 13 cytokines were measured within 72 h of stroke onset.

[A 66-year-old woman with confusion, aphasia, and myoclonus].

Background: Hashimoto's encephalopathy, also called steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a rare syndrome with an unknown pathogenesis. Clinical onset is insidious or acute with variable neurological symptoms. Spinal protein is elevated in most cases, but findings are non-specific in routine blood tests and on cerebral CT and EEG.

Fast electron transport and induced heating in solid targets from rear-side interferometry imaging.

Fast adiabatic plasma heating of a thin solid target irradiated by a high intensity laser has been observed by an optical fast interferometry diagnostic. It is driven by the hot electron current induced by the laser plasma interaction at the front side of the target. Radial and longitudinal temperature profiles are calculated to reproduce the observed rear-side plasma expansion.

Direct evidence of strongly inhomogeneous energy deposition in target heating with laser-produced ion beams.

We report on strong nonuniformities in target heating with intense, laser-produced proton beams. The observed inhomogeneity in energy deposition can strongly perturb equation of state (EOS) measurements with laser-accelerated ions which are planned in several laboratories. Interferometric measurements of the target expansion show different expansion velocities on the front and rear surfaces, indicating a strong difference in local temperature.

Generation of quasimonoenergetic electron bunches with 80-fs laser pulses.

Highly collimated, quasimonoenergetic multi-MeV electron bunches were generated by the interaction of tightly focused, 80-fs laser pulses in a high-pressure gas jet. These monoenergetic bunches are characteristic of wakefield acceleration in the highly nonlinear wave breaking regime, which was previously thought to be accessible only by much shorter laser pulses in thinner plasmas. In our experiment, the initially long laser pulse was modified in underdense plasma to match the necessary conditions.

Thomson-backscattered x rays from laser-accelerated electrons.

We present the first observation of Thomson-backscattered light from laser-accelerated electrons. In a compact, all-optical setup, the "photon collider," a high-intensity laser pulse is focused into a pulsed He gas jet and accelerates electrons to relativistic energies. A counterpropagating laser probe pulse is scattered from these high-energy electrons, and the backscattered x-ray photons are spectrally analyzed.

Laser-plasma acceleration of quasi-monoenergetic protons from microstructured targets.

Particle acceleration based on high intensity laser systems (a process known as laser-plasma acceleration) has achieved high quality particle beams that compare favourably with conventional acceleration techniques in terms of emittance, brightness and pulse duration. A long-term difficulty associated with laser-plasma acceleration--the very broad, exponential energy spectrum of the emitted particles--has been overcome recently for electron beams. Here we report analogous results for ions, specifically the production of quasi-monoenergetic proton beams using laser-plasma accelerators.

[Glossopharyngeal neuralgia].

Background: Glossopharyngeal neuralgia is a rare but nevertheless important condition as it can be very incapacitating and as effective treatment is available.

Material And Methods: We provide a review of the epidemiology, aetiology, differential diagnosis and treatment of this condition based on a Medline search.

Results And Interpretation: Glossopharyngeal neuralgia is characterised by severe unilateral pain in the posterior pharynx, tonsillar fossa, and base of the tongue.

[Doppler ultrasound of precerebral arteries. A retrospective study of referral routines and findings].

This study reports the activities of the cerebrovascular laboratory at Ullevål hospital in 1990. 713 patients (332 men and 381 women; mean age 60 years) were examined with pulsed Doppler ultrasound. Pathological findings were detected in 202 patients (28%).

[Treatment of writer's cramp with botulinum toxin].

Writer's cramp is a focal dystonia that is resistant to most treatment regimens. This article describes two patients with writer's cramp who were successfully treated with botulinum toxin injections into the forearm muscles. Transient weakness due to the effect of botulinum toxin was registered in the injected muscles.

The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: the Oslo Study.

We have investigated the effect of long-term strict glycaemic control on peripheral and autonomic nerve function in 45 IDDM patients (age 18-42 years, diabetes duration 7-23 years) without clinical signs of neuropathy or other neurological disease. They were randomly assigned to treatment either with continuous insulin infusion, multiple injections (4-6 times daily), or conventional treatment (twice daily) for 4 years and followed prospectively for 8 years. Motor and sensory nerve conduction velocities were measured at the start and after 8 years.

Grading stenoses of the internal carotid artery by estimation of blood velocity with pulsed Doppler ultrasound.

The relationship between blood velocity and residual lumen diameter at the origin of 100 internal carotid arteries was studied. The diameter was measured by angiography and blood velocity by relatively simple Doppler ultrasound equipment. A scatter diagram between maximal velocity and diameter was used to construct a table on the sensitivity and specificity of various cutoff values for maximal velocity to diagnose stenoses of different degrees.

Radiological assessment of stenosis of the internal carotid artery at the junction with the common.

Stenoses at the origin of 100 internal carotid arteries from patients with ischemic cerebrovascular disease were studied by intra-arterial angiography. Three principles were employed to evaluate the degree of stenosis: 1) verbal description, grading stenoses as mild, moderate of severe, 2) estimation of the true residual diameter, and 3) calculation of percent stenosis, defined here as the diameter of the artery at the origin relative to that at the level of the angle of the mandible. The true diameter, estimated to the nearest whole mm, corresponded well with the verbal description, and correlated significantly with percent stenosis.