Publications by authors named "Amsalu B Binegdie"
Rationale: Treatment outcomes may be compromised among patients with multidrug- or rifampicin-resistant tuberculosis with additional fluoroquinolone resistance. Evidence is needed to inform optimal treatment for these patients.
Objectives: We compared the effectiveness of longer individualized regimens comprised of bedaquiline for 5 to 8 months, linezolid, and clofazimine to those reinforced with at least 1 third-tier drug and/or longer duration of bedaquiline.
Article Synopsis
- * A study estimated treatment success probabilities for different BDQ durations (6 months, 7-11 months, and 12 months or more) among patients on individualized longer regimens, using methods to mitigate biases.
- * Results showed that treatment success rates were similar for BDQ durations of 6 months (85%) and 12 months (86%), while the 7-11 month group had a lower success rate (77%); extending BDQ beyond 6 months did not improve outcomes, highlighting the need for careful analysis in
Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but the prevalence and risk factors for schistosomiasis-associated PAH (SchPAH) development are not well understood. Schistosomiasis-associated hepatosplenic disease (SchHSD) is thought to be a major risk factor for PAH development. Herein, we describe our plans for prospectively screening SchHSD subjects for clinical evidence of PAH at two major academic medical centers and national referral hospitals in Addis Ababa, Ethiopia and Lusaka, Zambia.
View Article and Find Full Text PDFIntroduction: Lung cancer is the most common cause of cancer deaths worldwide, accounting for 1.8 million deaths each year. Only 20% of lung cancer cases are reported to occur in low- and middle-income countries.
View Article and Find Full Text PDFObjective: Uncontrolled asthma negatively impacts patients, families, and the community. The level of symptom control among asthmatics in Ethiopia has not been well studied. We investigated the level of asthma control and risk factors for poor asthma control in clinic patients seen in the largest public hospital in Ethiopia.
View Article and Find Full Text PDFBackground: Pulmonary tuberculosis (PTB) is one of the most common infectious diseases worldwide, and contributes significantly to morbidity and mortality in developing countries. Despite availability of effective treatment, a significant number of patients suffer from permanent lung damage, which predisposes patients to numerous pulmonary complications.
Objective: To assess chronic sequelae of patients treated for PTB in a chest clinic at Tikur Anbessa Hospital.