Publications by authors named "Amrut Mohapatra"
Background: Sputum eosinophils can be used to assess severity of disease and response to treatment in bronchial asthma. Eosinophilic inflammation in the airways can also be marked by blood eosinophilia. In this study, we tried to determine the sputum eosinophil count and serum absolute eosinophil count in patients with asthma and correlate them with disease severity and treatment response.
View Article and Find Full Text PDFIntroduction: COVID-19 pandemic hit Odisha province from April 2020 to December 2020, then from April 2021 to August 2021 and from February 2022 to April 2022 as the first, second, and third waves, respectively, with the most severe form witnessed during the second wave. Kalinga Institute of Medical Sciences hospital in Odisha was declared a Dedicated COVID Hospital (DCH) during those three waves and witnessed 9485 cases of admissions among which there were 1214 deaths. COVAXIN vaccination of the vulnerable population was launched in February 2021 onwards.
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- The study investigates the physiological changes in COVID-19 patients by analyzing qRT-PCR, CT scans, and biochemical parameters, highlighting the uncertain link between lung inflammation and these parameters.
- Among 1,136 patients, C-reactive protein (CRP) emerged as a key factor in differentiating symptomatic from asymptomatic cases, with elevated CRP levels associated with higher D-dimer, Gamma-glutamyl-transferase (GGT), and urea.
- The research introduces a deep learning method to enhance the accuracy of identifying ground-glass opacity (GGO) in lung CT scans, achieving significant accuracy compared to traditional manual methods, while emphasizing the need for broader studies across various populations to better understand how biochemical markers relate to
Article Synopsis
- Long COVID patients experience persistent multisystem symptoms lasting over four weeks post-infection, and pulmonary rehabilitation therapy may help improve their condition.
- A retrospective study analyzed data from 71 Long COVID patients, assessing measures like oxygen saturation, cough score, and biomarkers before and after three weeks of rehabilitation.
- Results showed significant improvements in various health parameters and normalization of inflammatory biomarkers, suggesting that pulmonary rehabilitation is beneficial for long COVID patients.
Article Synopsis
- - The study focused on understanding the factors behind acute exacerbations of chronic obstructive pulmonary disease (COPD) due to infections, involving patients admitted for treatment at Kalinga Institute of Medical Sciences from October 2018 to February 2022.
- - Researchers followed up on 197 patients, primarily elderly males and smokers from urban areas, identifying 102 pathogens responsible for exacerbations, with viral infections like rhinovirus and influenza being common, as well as various bacteria.
- - The results highlighted that males aged 61-80 years experienced the highest rates of exacerbation, and those with coinfections faced worse clinical outcomes, including higher readmission rates.
Article Synopsis
- The study compares the performance of the Abbott ID NOW test, a rapid point-of-care method, with the standard RT-PCR test for detecting SARS-CoV-2, the virus causing COVID-19, supported by WHO recommendations.
- A cross-sectional study involving 259 patients was conducted, and nasopharyngeal swabs were analyzed using both tests after obtaining proper ethical approval.
- Results showed that the ID NOW test had a sensitivity of 87% and specificity of 98%, making it a reliable rapid testing option compared to the standard RT-PCR method.
Background: Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is associated with high mortality, but there is limited clinical data on AE of interstitial lung disease (ILD) in connective tissue disease-associated ILD (CTD ILD). The present study was conducted to provide prevalence and clinical features of AE, as well as various risk factors associated with mortality among AE CTD ILD patients.
Methods: Between May 2013 and April 2018, 15 patients who developed AE among 105 consecutive patients with CTD with chronic ILD were included.