Lyophilized equine platelet-rich plasma (L-GF) antagonize the Reproductive toxicity and oxidative stress Induced by Cyclophosphamide in female rats.

Background: The antineoplastic agent Cyclophosphamide (CP) induces reproductive toxicity. New strategies for protecting ovarian tissue damage in women with chemotherapy-induced reproductive toxicity are essential. This study was designed to evaluate the possible protective effect of combined treatment with L-GF on CP-induced reproductive toxicity in the mature female rat.

Effect of oxygen tension and antioxidants on the developmental competence of buffalo oocytes cultured .

Aim: Oxidative stress (OS) is one of the major disruptors of oocyte developmental competence, which appears due to the imbalance between the production and neutralization of reactive oxygen species (ROS).

Materials And Methods: In Experiment 1, buffalo oocytes were matured, fertilized, and cultured at 38.5°C under 5% CO + 20% O in standard CO incubator (OS) or under 5% O + 5% CO + 90% N (Multi-gas incubator, low O).