Publications by authors named "Amro Alshareef"
Article Synopsis
- Postoperative ileus (POI) often causes extended hospital stays after abdominal surgery due to digestive tract paralysis, leading to symptoms like constipation and vomiting.
- Currently, treatments for POI are mainly supportive and not very effective, prompting the development of a new device called INSPIRE, which is an ingestible and self-propelling device designed to stimulate intestinal movement.
- In tests on swine models, the INSPIRE device significantly improved intestinal motility, with a 44% increase in normal cases and a 140% improvement in chemically induced ileus, drastically reducing the average passage time from 8.6 days to 2.5 days, making it a promising noninvasive treatment option for motility disorders.
Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension.
View Article and Find Full Text PDFEffective therapies for obesity either require invasive surgical or endoscopic interventions or high patient adherence, making it challenging for the nearly 42% of American adults who suffer from obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension.
View Article and Find Full Text PDFArticle Synopsis
- Peripheral nerve stimulation (PNS) has potential benefits for nerve repair and organ stimulation, but challenges like surgical placement and lead migration hinder its clinical use.
- The researchers developed adaptive, conductive, and electrotherapeutic scaffolds (ACESs), made from a hydrogel that supports both traditional and minimally invasive surgical techniques.
- In studies with rodents and pigs, ACESs showed significant improvements in nerve recovery and muscle health, along with easier lead removal, paving the way for effective therapeutic PNS applications.
Article Synopsis
- Oral drug delivery of proteins usually requires injections due to poor absorption in the gastrointestinal tract and mucus barriers.
- The RoboCap is a robotic capsule designed to clear mucus and mix contents in the small intestine to improve drug absorption.
- In studies with swine models, RoboCap significantly enhanced the absorption of vancomycin and insulin, demonstrating its potential for effective oral delivery of traditionally difficult-to-absorb medications.