Endothelial Cpt1a Inhibits Neonatal Hyperoxia-Induced Pulmonary Vascular Remodeling by Repressing Endothelial-Mesenchymal Transition.

Pulmonary hypertension (PH) increases the mortality of preterm infants with bronchopulmonary dysplasia (BPD). There are no curative therapies for this disease. Lung endothelial carnitine palmitoyltransferase 1a (Cpt1a), the rate-limiting enzyme of the carnitine shuttle system, is reduced in a rodent model of BPD.

HGF-induced formation of the MET-AXL-ELMO2-DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion.

The proto-oncogene-encoded receptor tyrosine kinase (MET) and AXL receptor tyrosine kinase (AXL) are independently operating receptor tyrosine kinases (RTKs) that are functionally associated with aggressive and invasive cancer cell growth. However, how MET and AXL regulate the migratory properties of cancer cells remains largely unclear. We report here that the addition of hepatocyte growth factor (HGF), the natural ligand of MET, to serum-starved human glioblastoma cells induces the rapid activation of both MET and AXL and formation of highly polarized MET-AXL clusters on the plasma membrane.

Demography and diagnosis of patients encountered at Qassim University Polyclinics, Central Saudi Arabia.

Objectives: To provide current data on the demography and diagnosis of patients encountered at the Internal Medicine Outpatient Department of Qassim University Polyclinics (QUP), Qassim, Kingdom of Saudi Arabia (KSA). 

Methods: A cross-sectional descriptive study conducted at QUP, Qassim, KSA, during the period November 2014 and December 2015. The record files of the study patients who were sampled by convenience method, were reviewed and analyzed.