Publications by authors named "Amrish Rai"
ACS Chem Neurosci
August 2024
Article Synopsis
- TTK21 is a small molecule that enhances a specific enzyme's activity crucial for brain function, and when combined with a glucose-derived carbon nanosphere (CSP), it can successfully cross the blood-brain barrier and promote brain cell growth and memory retention.
- The study shows that CSP-TTK21 can be effectively delivered through oral administration, comparing its effects to traditional intraperitoneal (IP) injection in mice.
- Findings reveal that oral CSP-TTK21 boosts synaptic strength in the hippocampus and improves motor function and gene expression related to recovery in a spinal injury model, all without toxic effects at high doses.
