Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of and Rich Phenolic Formula on Lipid Metabolism and Plasma Lipoprotein Oxidation in Mice Fed a High-Fat Diet: A Follow-Up Study.

Background/objectives: Hyperlipidemia is a serious risk factor for cardiovascular diseases and liver steatosis. In this work, we explored the effect of an herbal formula (CBF) containing immature pods and extracts on lipid metabolism disorders and lipoprotein-rich plasma (LRP) oxidation in mice.

Methods: The phenolic composition was determined using HPLC-DAD analysis.

Relationship Between Blood Groups and Cardiovascular Diseases: Insights From an Algerian Inpatient Study.

Introduction:  Research on the association between blood groups and cardiovascular diseases (CVDs) in Africa, including Algeria, is notably limited, with a primary focus on blood donors. This narrow scope hinders a comprehensive understanding of the genetic diversity of blood groups and their potential links to CVD risk within the African context. To bridge this knowledge gap, this study proposes to investigate the distribution of blood group genotypes and their association with CVD prevalence, aiming to enhance knowledge within the African context and contribute to global insights into the relationship between blood groups and CVD.

Effects of L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression.

Hyperlipidemia is a major contributor to metabolic complications and tissue damage, leading to conditions such as liver steatosis, atherosclerosis, and obesity. This study aimed to investigate the effects of aqueous artichoke bract extract (AE) on lipid metabolism, liver antioxidative defense, and liver steatosis in mice fed a high-fat, high-sucrose diet while elucidating the underlying mechanisms. An 8-week study used hyperlipidemic mice treated with AE at daily doses of 100 and 200 mg/kg bw, compared to fenofibrate.

Chemical Composition, Antioxidant Activity, and Multivariate Analysis of Four Moroccan Essential Oils: and .

Food chemical antioxidants have demonstrated protective effects against reactive oxygen species and free radicals, but present in excess, harmful consequences might occur on health. Therefore, replacing these synthetic additives with nontoxic natural antioxidants is crucial. The current study examined aroma profile, antioxidant activity, and multivariate analysis of , , , and essential oils from Morocco.

Metabolic Effects of Loquat Juice ( Lindl Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat-High-Fructose Diet.

Background: Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, and carotenoids. This study aimed at the biochemical characterization of fresh juice from the Moroccan variety of loquat and evaluating its effects on lipid homeostasis and liver steatosis in hyperlipidemic mice.

Methods: The biochemical characterization followed AOAC methods.

Expression of JAK/STAT Signaling Proteins at Diagnosis and Remission in Patients with Acute Myeloid Leukemia.

Objectives: Acute myeloid leukemia (AML), among other malignancies, has been linked to the deregulation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway, which is essential for cell growth, proliferation, and differentiation. This study aimed to investigate the expression of JAK/STAT proteins at diagnosis and remission and how it affects overall survival (OS).

Methods: This is a prospective study conducted in the College of Medicine, Sultan Qaboos University.

Medical Tourism and Neurological Diseases: Omani Patients' Experience Seeking Treatment Abroad.

Objectives: There is a dearth of research regarding the motivations and experiences of Omani nationals who travel abroad for medical treatment, especially for neurological diseases. The primary objective was to examine and draw comparisons between Omani adults and children with neurological disorders who pursued medical treatment abroad after being evaluated by local specialists. The study also aimed to gain insights into these patients' motivations and experiences.

Nutritional Composition and Effect of Loquat Fruit ( L. var. ) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice.

Loquat ( L.) is a popular fruit known for its sweet and slightly tangy flavor, which is widely consumed both fresh and in various processed forms. This study aimed to analyze the biochemical composition of loquat juice and investigate its metabolic benefits in mice fed a high-fat/high-sucrose diet (HFSD).

Trustworthy Artificial Intelligence in Dentistry: Learnings from the EU AI Act.

Artificial intelligence systems (AISs) gain relevance in dentistry, encompassing diagnostics, treatment planning, patient management, and therapy. However, questions about the generalizability, fairness, and transparency of these systems remain. Regulatory and governance bodies worldwide are aiming to address these questions using various frameworks.

Primary extra hepatic hydatid cyst of the kidney: A case report.

Human echinococcosis (hydatid disease) is highly endemic in Morocco and reemerging as a significant public health problem in this country. It is a cyclozoonotic infection introduced by , that can invade any organ in the human body. The liver is the mostly affected organ, which is the primary site of human infestation, followed by lungs.

Stable population structure in Europe since the Iron Age, despite high mobility.

Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000-3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.

Intravitreal faricimab as an adjuvant in the management of tubercular uveitis.

Purpose: To report the use of intravitreal faricimab used as an adjunct in the management of intraocular tuberculosis (IOTB) in a patient with occlusive retinal vasculitis (ORV) and choroiditis.

Methods: A case report.

Results: A 27-year-old Asian male presented with bilateral choroiditis and ORV complicated by retinal neovascularization and vitreous hemorrhage in one eye.

Immature carob pods extract and its fractions prevent lipid metabolism disorders and lipoprotein-rich plasma oxidation in mice: A phytochemical and pharmacological study.

Ethnopharmacological Relevance: In Morocco carob fruits are used traditionally to treat hypercholesterolemia, diabetes and related diseases.

Aims: This study was designed to evaluate the hypolipidemic activity of Ceratonia siliqua green pods extract and its fractions in Triton WR-1339 and high fat/cholesterol diet (HFCD) induced hyperlipidemia mice, as well as their ability to prevent lipoproteins oxidation in vitro.

Materials And Methods: High performance liquid chromatography (HPLC) analysis was used to determine the phenolic composition of the immature carob pods extract (HWCE).

(Ball) Roussine Aqueous Extract Exerts Lipid-lowering and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs.

Background: Thymus atlanticus (Ball) Roussine (T. atlanticus) is traditionally used in the Moroccan high Atlas Mountains to treat several disorders, including cardiovascular disease. In the present study, the lipid-lowering and anti-atherosclerotic activities of the traditionally used aqueous extract of T.

A genetic history of continuity and mobility in the Iron Age central Mediterranean.

The Iron Age was a dynamic period in central Mediterranean history, with the expansion of Greek and Phoenician colonies and the growth of Carthage into the dominant maritime power of the Mediterranean. These events were facilitated by the ease of long-distance travel following major advances in seafaring. We know from the archaeological record that trade goods and materials were moving across great distances in unprecedented quantities, but it is unclear how these patterns correlate with human mobility.

Anti-Inflammatory Study and Phytochemical Characterization of Roscoe and L. Juices and Their Formulation.

and , well known as ginger and lemon, are two vegetals widely used in traditional medicine and the culinary field. The juices of the two vegetals were evaluated based on their inflammation, both in vivo and in vitro. High-performance liquid chromatography (HPLC) was used to characterize different juices from Roscoe and .

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: study and prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites.

Hyperlipidemia is the most well-known cause of metabolic complications and tissue toxicity such as liver steatosis, atherosclerosis and obesity. This study aims to evaluate the preventive effect of loquat fruit peel extract (PE) against tyloxapol-induced hyperlipidemia and related tissue lipotoxicity in mice. The study was conducted on mice injected daily with tyloxapol at 100 mg per kg B.

Synchronous bilateral breast cancer: A first case with lobular and mucinous carcinoma.

This report describes a rare case of synchronous bilateral carcinoma of the breast in a postmenopausal female patient, with mucinous carcinoma measuring 5 cm in the left breast and multifocal multicentric lobular carcinoma in the right breast. The patient underwent a bilateral mastectomy with adjuvant chemotherapy. To the best of our knowledge, this is the first report of a case of mucinous carcinoma and infiltrating lobular carcinoma coexisting in distinct breasts.

Gamma-irradiation effect on the chemical composition and antibacterial activity of the moroccan L. essential oil.

The primary objective of the present inquiry was to assess the impact of gamma irradiation on the chemical composition and antibacterial potential of the essential oil extracted from the aerial parts of Moroccan L. to this end, two distinct irradiation doses of 5 kGy and 10 kGy were administered to the essential oil, and the resultant effects were evaluated via analysis of the oil's chemical composition and antibacterial activity. The study findings have revealed that irradiation technology possesses the remarkable ability to modulate the concentrations of specific chemical constituents in a manner that effectively amplifies the antibacterial activity of the essential oil.

Microbiological Profile and Hygienic Quality of Foodstuffs Marketed in Collective Catering in Central Morocco.

Food hygiene is important both for its impact on the health of citizens and also for the cost of the infections that it can generate. In Morocco, it has become a concern of authorities. This work, realized for the first time in the center of Morocco, is aimed at describing the microbiological quality of foodstuffs marketed in collective catering in central Morocco.

Environmental conditions of recognition memory testing induce neurovascular changes in the hippocampus in a sex-specific manner in mice.

Experiences are linked to emotions impacting memory consolidation and associated brain neuronal circuits. Posttraumatic stress disorder is an example of strong negative emotions affecting memory processes by flashbacks of past traumas. Stress-related memory deficits are also observed in major depressive disorder (MDD).

Loquat fruit peel extract regulates lipid metabolism and liver oxidative stress in mice: In vivo and in silico approaches.

Ethnopharmacological Relevance: In Moroccan traditional medicine, fresh or dried loquat (Eriobotrya japonica (Thunb.) Lindl.) fruit peels infused in water and taken for 45 days are used as natural remedies against hypercholesterolemia, hyperglycemia and cardiovascular diseases.