Publications by authors named "Amran Daher Abdi"
Article Synopsis
- Obesity not only increases the risk of type 2 diabetes and cardiovascular diseases but is also linked to learning disabilities, possibly due to dysregulation in the kynurenine pathway (KP) of tryptophan metabolism.
- This study examined the effects of an obesity-inducing high-fat high-sugar diet on learning capacity in Wistar rats, finding that male obese rats showed reduced learning and increased levels of harmful metabolites in the brain, particularly in the hippocampus.
- The findings suggest that obesity-related cognitive impairment may be influenced by sex differences and may stem from changes in KP metabolism, specifically the increased production of quinolinic acid (QA), which negatively affects learning.
Maternal supplementation during pregnancy with docosahexaenoic acid (DHA) is internationally recommended to avoid postpartum maternal depression in the mother and improve cognitive and neurological outcomes in the offspring. This study was aimed at determining whether this nutritional intervention, in the rat, protects the offspring against the development of obesity and its associated metabolic disorders. Pregnant Wistar rats received an extract of fish oil enriched in DHA or saline (SAL) as placebo by mouth from the beginning of gestation to the end of lactation.
View Article and Find Full Text PDFAdult rats from undernourished dams show sex-dependent impaired expression in taste papillae and hypothalamus of genes responsible for sweet and fat detection and signalling.
Sandra Olvera Hernández Luis Antonio Reyes Castro Amran Daher Abdi Carla Elena Mezo-González Armando Arredondo
Nutr Neurosci
October 2022
Article Synopsis
- The study investigates how being undernourished during pregnancy or early life affects taste detection and food preferences, leading to increased consumption of sugary and fatty foods in adulthood.* -
- Researchers compared gene expression related to taste and food intake regulation between rats born to well-nourished and calorie-restricted mothers.* -
- Findings reveal that maternal undernutrition results in sex-specific changes in gene expression and food preferences, with male rats showing a stronger inclination for sweet and fatty foods compared to females.*