Publications by authors named "Amr Marawan"
Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are two methods used to detect hemodynamically significant lesions and guide revascularization. Discrepancies between FFR and iFR values can complicate revascularization decisions. We present a series of six cases with discrepant FFR and iFR results.
View Article and Find Full Text PDFSafety, Tolerability, and Effects of a Single Subcutaneous Administration of SP16 - a SERPIN-like, Small Peptide Agonist of the Low-Density Lipoprotein-like Receptor 1- on the Acute Inflammatory Response in Patients With ST-Segment Elevation Myocardial Infarction.
J Cardiovasc Pharmacol
November 2022
Background: Modulation of the inflammatory response is a promising therapeutic strategy in acute myocardial infarction. The novel approach is based on the anti-inflammatory and cytoprotective properties mediated by the engagement of the low-density lipoprotein‒related protein 1 (LRP1) receptor. SERPIN peptide 16 (SP16) is a synthetic, selective LRP1 agonist.
View Article and Find Full Text PDFArticle Synopsis
- Heart failure (HF) is a major global health issue, and there is a need for new treatment strategies, which may include the use of anakinra, an IL-1 receptor antagonist.
- A clinical trial is being conducted with 102 adult patients who were recently hospitalized for acute decompensated heart failure and systemic inflammation, to test the effects of anakinra compared to a placebo over 24 weeks.
- The primary goal of the trial is to measure improvements in peak oxygen consumption during exercise, along with secondary evaluations of heart health, quality of life, and other relevant outcomes.
Importance: Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little is known about the genetic underpinnings of the growing numbers of patients with DCM who are diagnosed when they are older than 60 years (ie, late-onset DCM).
Objective: To investigate the prevalence, type, and prognostic impact of disease-associated rare variants in patients with late-onset DCM.
Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure.
J Cardiovasc Pharmacol
October 2020
The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral inhibitor of the NLRP3 inflammasome, dapansutrile (OLT1177), in patients with heart failure and reduced ejection fraction (HFrEF). This was a phase 1B, randomized, double-blind, dose escalation, single-center, repeat dose safety and pharmacodynamics study of dapansutrile in stable patients with HFrEF (New York Heart Association Class II-III).
View Article and Find Full Text PDFEstimated plasma volume and mortality: analysis from NHANES 1999-2014.
Clin Res Cardiol
September 2020
Background: While estimated plasma volume (ePV) has been studied in some diseases, such as heart failure, the relationship between ePV and all-cause or cause-specific mortality remains unexplored. Therefore, we investigated the association between ePV and all-cause, cardiovascular (CV), and cancer-related mortality among adults in the US.
Method: We used the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014 and included participants older than 18 years.
Aims: The small number of studies that have investigated the relationship between serum vitamin D levels and cardiorespiratory fitness (CRF) have reported conflicting results. We investigated the association between vitamin D levels and CRF in a representative sample of the US population using data from the National Health and Nutrition Survey (2001-2004).
Methods: We included participants between the ages of 20 and 49 years and excluded those with vitamin D levels at the 5% extremes of the distribution.