Publications by authors named "Amr Hassan"
Background: Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothelial function and reduce vascular wall inflammation. A growing body of research suggests that statins are associated with less risk of migraine, and they can be used to treat symptoms. However, the evidence has been inconclusive, so we aim to investigate the nature and strength of the effect of statins on the prevention and prophylaxis of migraines.
View Article and Find Full Text PDFPurpose: To evaluate the efficacy and safety of the Paul Glaucoma Implant (PGI) surgery in patients with secondary glaucomas.
Patients And Methods: Retrospective chart review of adult patients with medically recalcitrant secondary glaucoma who underwent PGI implantation at a single tertiary center between August 2022 and June 2023. The primary outcome measure was surgical success.
Background: Naming is an important part of human communication. The precision of medical terms greatly influences the patients and their caregivers. "Alsara'الصرع " is the Arabic term defining epilepsy.
View Article and Find Full Text PDFSheath blight, caused by AG1 IA, is a challenging disease of rice worldwide. In the current study, nine isolates, within the anastomosis group AG-1 IA, were isolated, characterized based on their macroscopic and microscopic features, as well as their ability to produce cell wall degrading enzymes (CWDEs), and further molecularly identified via ITS sequencing. Although all isolates were pathogenic and produced typical sheath blight symptoms the susceptible rice cultivar, Sakha 101, AG1 IA -isolate SHBP9 was the most aggressive isolate.
View Article and Find Full Text PDF: To study and evaluate the change in retinal nerve fiber layer (RNFL) and macular thickness and its clinical correlation with visual outcome following amblyopia therapy. : In this prospective interventional study, children with moderate to severe amblyopia were given optical correction and part-time occlusion therapy. Visual assessment and optical coherence tomography (OCT) were performed at days 0 and 3, 6 months of follow-up.
View Article and Find Full Text PDFBackground: The diagnosis of acute myocardial infarction is straightforward when it presents with typical symptoms. However, some patients can be asymptomatic, and some can present with atypical symptoms.
Case Presentation: We present a very rare case of acute myocardial infraction that presented with headache and right upper limb numbness of 2-day duration in a 61-year-old female Middle Eastern patient.
YouTube as a Source of Knowledge for Childhood Glaucoma.
J Pediatr Ophthalmol Strabismus
December 2024
Purpose: To evaluate the quality and reliability of patient-targeted videos about childhood glaucoma on the YouTube platform.
Methods: On March 1, 2024, a search was performed on YouTube (www.youtube.
Background: The Migraine-Specific Quality-of-Life Questionnaire version 2.1 (MSQ 2.1) is one of the most frequently used tools in assessing the impact of migraine in clinical practice and in migraine research.
View Article and Find Full Text PDFBackground: For individuals with multiple sclerosis (MS), treatment interruption can result in relapse/recurrence of the disease activity. Currently, there are no consensus guidelines about whether an abrupt stop with a short washout period or gradual tapering is better for fingolimod (Gilenya) cessation. We investigated the impact of the fingolimod discontinuation strategy on the recurrence of disease activity and the rebound occurrence of symptoms during washout.
View Article and Find Full Text PDFTo compare the outcomes of rAAV2-ND4 injection in treated versus fellow eyes with Leber's hereditary optic neuropathy (LHON). The protocol was pre-registered on PROSPERO (CRD42023441669). PubMed, Ovid MEDLINE, Cochrane CENTRAL, Google Scholar, Embase, CrossRef, OpenAlex, and Web of Science were reviewed from 1990-2023.
View Article and Find Full Text PDFBackground: Recent discoveries have illustrated that Lin28A is an oncogene in various cancers, particularly acute myeloid leukemia (AML). The upregulation of Lin28A can actively contribute to tumorigenesis and migration processes in multiple organs. Hence, the inhibition of Lin28A can be achieved by applying phytochemical herbals and targeting Lin28A protein using a computer-aided drug design (CAAD) approach.
View Article and Find Full Text PDFBackground And Objectives: We evaluated the performance of 3 large language models (LLMs) in generating patient education materials (PEMs) and enhancing the readability of prewritten PEMs on idiopathic intracranial hypertension (IIH).
Methods: This cross-sectional comparative study compared 3 LLMs, ChatGPT-3.5, ChatGPT-4, and Google Bard, for their ability to generate PEMs on IIH using 3 prompts.
Purpose: To identify risk factors and effect modifiers associated with intraocular inflammation (IOI) following brolucizumab injection.
Methods: Our protocol was registered on PROSPERO (CRD42022382645). We searched six electronic databases (PubMed, Scopus, Web of Science, CENTRAL, EMBASE, and Google Scholar) to retrieve all studies that reported the occurrence of IOI following brolucizumab.
Purpose: To evaluate the effectiveness and safety of trabeculectomy compared to glaucoma drainage devices (GDDs) in managing uveitic glaucoma (UG).
Design: Systematic review.
Methods: We searched seven electronic databases (PubMed, Scopus, Web of Science, ScienceDirect, EMBASE, CENTRAL, and Google Scholar) to compare trabeculectomy with various GDDs in UG.
Article Synopsis
- Purtscher's and Purtscher-like retinopathies are rare eye conditions characterized by specific visual symptoms and potentially severe outcomes, primarily linked to trauma or systemic diseases such as systemic lupus erythematosus.
- A study analyzed 114 articles covering 168 cases, finding that trauma was the leading cause in nearly 40% of patients, and the average age of patients was around 34.6 years.
- Most patients experienced bilateral vision problems, with symptoms like blurred vision, cotton-wool spots, and Purtscher flecken being common; overall, about 53% had a favorable visual prognosis.
Article Synopsis
- The study investigates racial, ethnic, and sex disparities in enrollment for Pediatric Eye Disease Investigator Group (PEDIG) clinical studies, comparing the demographic data to the 2010 US Census for the pediatric population.
- It analyzes data from PEDIG studies conducted in the US between 1997 and 2022, focusing on race, ethnicity, and sex of participants using various sources including published studies and ClinicalTrials.gov.
- Results include statistical comparisons of enrollment percentages, identifying underrepresentation or overrepresentation of specific groups, and examining factors influencing these disparities.
Article Synopsis
- This study assessed how well three large language models (LLMs) - ChatGPT-3.5, ChatGPT-4, and Google Bard - could create and improve patient education materials (PEMs) for pediatric cataract.
- Researchers compared the responses from the LLMs based on prompts that varied in complexity and readability levels, specifically targeting sixth-grade understanding.
- Results showed that all LLMs produced high-quality and accurate materials, with ChatGPT-4 standing out for generating the most readable PEMs, effectively lowering the complexity to meet the specified reading level.
Article Synopsis
- * A committee of headache experts identified clinical questions and reviewed twenty-one national and international guidelines to develop these recommendations.
- * The guidelines outline seventeen questions related to acute migraine treatment, aiming to enhance treatment quality globally, especially in areas with limited medication access.
and methicillin-resistant (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such as glycyrrhizic acid are recognized as efficient bactericides against a wide range of bacterial strains. Recently, scientists have shown interest in plant extract nanoparticles, derived from natural sources, which can be synthesized into nanomaterials.
View Article and Find Full Text PDFPurpose: To review all studies reporting the occurrence of white dot syndromes (WDSs) following SARS-COV-2 infection.
Methods: On May 12, 2023, we registered our protocol on PROSPERO [registration number: CRD42023426012]. Five different databases including PubMed, Scopus, Web of Science, Google Scholar, and Science Direct were searched up to May 2023.
Purpose: To review all studies reporting the onset of white dot syndromes following COVID-19 vaccines.
Methods: Our protocol was registered prospectively on PROSPERO [registration number: CRD42023426012]. We searched five different databases including PubMed, Scopus, Web of Science, Google Scholar, and Science Direct up to May 2023.
Background: The Headache Impact Test (HIT-6) is an important patient-reported outcome measure (PROM) in migraine prevention trials.
Objectives: This study aimed to (i) assess the reliability and validity of the Arabic version of HIT-6 in Arabic-speaking patients experiencing migraine, and (ii) evaluate the responsiveness of HIT-6 following migraine preventive therapy.
Methods: In this prospective study, patients with migraine (n = 145) were requested to fill out a headache diary, the Arabic version of HIT-6, and Migraine Disability Assessment Scale (MIDAS) at two time points (baseline and 3 months after initiation of prophylactic treatment).
Purpose: To evaluate the quality, readability, and accuracy of large language model (LLM)-generated patient education materials (PEMs) on childhood glaucoma, and their ability to improve existing the readability of online information.
Design: Cross-sectional comparative study.
Methods: We evaluated responses of ChatGPT-3.
Background: To evaluate the quality & reliability, technical quality, and readability of patient-targeted online information on idiopathic intracranial hypertension.
Methods: In this cross-sectional study, we searched Google and Bing search engines for the terms "idiopathic intracranial hypertension" and "pseudotumor cerebri." We evaluated the first 50 search outcomes for each search term.