Publications by authors named "Amr Alwakeal"
Objectives: Four-factor prothrombin complex concentrate (4-PCC) is recommended for rapid reversal of vitamin K antagonists (VKAs) such as warfarin, yet optimal dosing remains uncertain.
Data Sources: A systematic review was conducted of PubMed, Embase, and Ovid MEDLINE (Wolters Kluwer) databases from January 2000 to August 2023 for clinical studies comparing fixed- vs. variable-dose 4-PCC for emergent VKA reversal with at least one reported clinical outcome.
Article Synopsis
- - The study aimed to analyze the relationship between obesity and meningioma in patients undergoing craniotomy, comparing male and female patients' BMI and survival outcomes with those facing other intracranial tumors.
- - Researchers used data from the National Surgical Quality Improvement Program (NSQIP) and collected additional institutional data, finding that both male and female meningioma patients were more likely to be overweight or obese compared to patients with other tumors.
- - Meningiomas were found more often in the skull base among males, but the progression-free survival (PFS) rates did not differ between obese and nonobese patients of either gender, with obesity increasing the risk of pulmonary embolism in both groups.
Objective This study examined the interaction between adolescent idiopathic scoliosis (AIS) and pregnancy, focusing on pregnancy outcomes, changes in back pain, and anesthesia use. Methods A retrospective analysis was conducted on adult patients with AIS who gave birth at our institution between 2006 and 2022. Results A total of 163 AIS patients with 263 pregnancies were included.
View Article and Find Full Text PDFObjective: Radionuclide shuntography (RS) performed using 99mTc-DTPA injected into the reservoir of CSF shunts enables evaluation of CSF flow for suspected shunt malfunctions. The goal of this study was to report the authors' institutional experience with RS and evaluate its utility and associated complications.
Methods: The authors retrospectively reviewed all RS studies performed between November 2003 and June 2022.
Objective: Despite significant recent efforts applied toward the development of efficacious therapies for glioblastoma (GBM) through exploration of GBM's genome and transcriptome, curative therapeutic strategies remain highly elusive. As such, novel and effective therapeutics are urgently required. In this study, the authors sought to explore the kinomic landscape of GBM from a previously underutilized approach (i.
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