Bevacizumab Allows Preservation of Liver Function and its Regenerative Capacity after Major Hepatectomy.

Background: Parallel to the safety of liver resections, new chemotherapy drugs have emerged for the control of liver metastases. However, there is unclear evidence about the combination of intensive BVZ-therapy and extended resections. The main aim was to analyse the impact of Bevacizumab (BVZ) in terms of liver safety and tolerability in two experimental models: a basal-toxicity situation and after major hepatectomy.

Impact of age on liver regeneration response to injury after partial hepatectomy in a rat model.

Background: Liver resection is a feasible treatment for multiple liver diseases. There is no evidence about the impact of age on liver regeneration.

Objective: To assess the effect of age on liver regeneration in an experimental in vivo animal model of 70%-partial hepatectomy.