Publications by authors named "Amparo Meoro-Aviles"
Article Synopsis
- Genetic diagnosis for pheochromocytoma and paraganglioma is crucial, as around 80% of cases have identifiable driver mutations, prompting the need for efficient testing methods.
- This study focused on optimizing targeted next-generation sequencing (NGS) to analyze 18 key PPGL genes in both germline and tumor DNA, validating two customized NGS assays with a diverse group of 453 patients.
- The NGS assays demonstrated over 99% sensitivity and identified numerous mutations, including 89 pathogenic mutations, proving to be a reliable alternative to traditional sequencing methods and useful for patients with unclear clinical histories.
Background: Nowadays, 65-80% of pheochromocytoma and paraganglioma (PPGL) cases are explained by germline or somatic mutations in one of 22 genes. Several genetic testing algorithms have been proposed, but they usually exclude sporadic-PPGLs (S-PPGLs) and none include somatic testing. We aimed to genetically characterise S-PPGL cases and propose an evidence-based algorithm for genetic testing, prioritising DNA source.
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- Diabetes education is crucial for managing type 1 diabetes, and the VII Area Murcia East Diabetes Unit has integrated advanced-trained nurses to enhance patient care at the Hospital General Universitario Reina Sofía.
- A retrospective study analyzed data from 179 type 1 diabetes patients over 11 years, revealing a patient population mostly comprised of middle-aged individuals with a mean age of 38.25 years.
- The study found a significant reduction in HbA1c levels (from 8.49% to 7.86%) after six months of education, indicating improved diabetes management, while insulin doses remained stable throughout the research period.
Background And Objectives: Sporadic adrenomedullary hyperplasia (AMH) is characterized by a medical history of hypertension, excessive catecholamine excretion, and histomorphometric evidence of increased adrenomedullary tissue relative to the cortex in the absence of multiple endocrine neoplasia. The aim of this study was to perform a retrospective analysis of patients after laparoscopic adrenalectomy for AMH, an early form of sporadic adrenal medulla-related endocrine hypertension, as well as to update our understanding of the clinical features and management of this clinicomorphologic entity.
Methods: We performed a retrospective review of the medical records of patients operated on between 2007 and 2011 at Reina Sofia University General Hospital, Murcia, Spain, with a diagnosis of AMH.
Introduction: The purpose of this study is to measure the impact of a psychoeducational group intervention in diabetes using glycosylated haemoglobin (HbA1c), the body mass index (BMI) and cardiovascular risk factors (CVRF) compared with conventional educational measures provided individually.
Methods: A quasi-experimental study (pre/post-intervention) with a non-equivalent control group was conducted, including 72 type 2 individuals with diabetes (mean data: age 63.08 years, HbA1C 6.
Case (description) the patient is a 20 years old male smoker, who was diagnosed with type 2 diabetes mellitus in 2006. Due to the inadequate response to the previously established treatment, the pharmacotherapy was modified by introducing exenatide (up to 10 μg, twice daily) instead of insulin glargine, but maintaining the treatment with the diuretic and angiotensin II receptor antagonist drugs. Two months later, the patient exhibited a very important intolerance to exenatide (continuous nausea, vomiting, and dehydration), finally leading to ischemic acute renal failure.
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