Effect of geometrical structure variations on strength and damage onset of cortical bone using multi-scale cohesive zone based finite element method.

Three-dimensional multi-scale finite element models were designed to examine the effects of geometrical structure variations on the damage onset in cortical bone at multiple structural scales. A cohesive zone finite element approach, together with anisotropic damage initiation criteria, is used to predict the onset of damage. The finite element models are developed to account for the onset of microdamage from the microscopic length scales consisting of collagen fibres, to the macroscopic level consisting of osteons and the Haversian canals.

Effect of geometrical structure variations on the viscoelastic and anisotropic behaviour of cortical bone using multi-scale finite element modelling.

Multi-scale finite element analysis is performed to ascertain the effect of geometrical changes at multiple structural scales on the mechanical properties of cortical bone. Finite element models are developed, with reference to experimental data from existing literature, to account for bone's viscoelastic behaviour and anisotropic structure from the most fundamental level of bone consisting of mineralised collagen fibrils, up to the macroscopic level consisting of osteons and the Haversian canals. A statistical approach is incorporated to perform sensitivity analyses on the effects of different geometrical parameters on the effective material properties of cortical bone at each length scale.