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Publications by authors named "Amos B Smith"

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Synopsis of recent research by authors named "Amos B Smith"

  • - Amos B. Smith's recent research focuses on the structural dynamics of the HIV-1 envelope glycoprotein (Env), particularly emphasizing the transitions between its conformations that affect susceptibility to therapies and immune responses.
  • - His findings highlight the role of CD4-mimetic compounds in stabilizing the pretriggered conformation of Env, enabling non-neutralizing antibodies to recognize and mediate antibody-dependent cellular cytotoxicity (ADCC) against HIV-1-infected cells.
  • - The studies further reveal that certain antibody combinations can significantly enhance ADCC potency when paired with CD4-mimetics, demonstrating potential strategies for improving therapeutic interventions against HIV-1.

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